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Metronidazole for Helicobacter pyloriHelicobacter pylori eradication therapy among children and adolescents in Japan: Overcoming controversies and concerns

机译：甲硝唑为幽门螺杆菌幽门螺杆菌 - 幽门螺杆菌在日本儿童和青少年的根除治疗：克服争论和关注

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Abstract <section numbered="no" xml:id="hel12575-sec-0001"> <title type="main">Background > Metronidazole is an antiprotozoal drug used to treat a broad spectrum of infectious diseases, including Helicobacter pylori ( H?pylori ) infections. In Japan, metronidazole is approved for the eradication therapy of H?pylori as a second‐line regimen among adults, but it has not yet been approved for use among children and adolescents. </section> <section numbered="no" xml:id="hel12575-sec-0002"> <title type="main">Materials and Methods >To perform this narrative review, we searched the relevant literature on important events in the history of the use of metronidazole, its mechanisms of action, its efficacy, and the adverse effects reported in clinical trials or cohort studies in Japan. </section> <section numbered="no" xml:id="hel12575-sec-0003"> <title type="main">Results >At present, metronidazole resistance has not been a serious issue in Japan in large part due to its restricted use. Emerging evidence from randomized controlled trials demonstrates higher eradication rates for metronidazole than for clarithromycin, supporting its use in both first‐line and second‐line eradication therapies. Among the reported adverse effects, there has been lingering concern over the potential carcinogenicity of metronidazole in humans. However, the possibility of an increased cancer risk is not limited to metronidazole; the long‐term use of antibiotics has been linked to increased risk for some site‐specific cancers. However, recent prospective studies have suggested that short‐term exposure to antibiotics is not associated with an increased cancer risk.< </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“main”XML：ID =“Hel12575-Abs-0001”XML：Lang =“en”> <标题类型=“main”>抽象</ title> <secueded =“no”xml：id = “Hel12575-SEC-0001”> <标题类型=“main”>背景</标题> >甲硝唑是一种用于治疗广谱的传染性疾病的反气化药物，包括幽门螺杆菌（ H？幽门螺杆菌）感染。在日本，甲硝唑被批准用于根除治疗 H？Pylori </ i>作为成人中的第二行方案，但尚未批准用于儿童和青少年。 </ p> </ section> <secto numbyed =“no”xml：id =“hel12575-sec-0002”> <标题类型=“main”>材料和方法</ title> >执行这一叙述评论，我们在甲硝唑史上的重要事件中搜索了相关文献，其作用机制，其疗效以及日本临床试验或队列研究中报告的不利影响。</ p> </段> <截面编号=“否”XML：ID =“Hel12575-SEC-0003”> <标题类型=“main”>结果</标题> >目前，甲硝唑抗性在日本的大部分缺乏是一个严重的问题限制使用。来自随机对照试验的新兴证据证明了甲硝唑的根除率高，而不是克拉霉素，支持其在一线和二线根除疗法中的用途。在报告的不利影响中，对人类甲硝唑的潜在致癌性进行了担忧。然而，增加癌症风险的可能性不仅限于甲硝唑;长期使用抗生素与某些位点特异性癌症的风险增加有关。然而，最近的前瞻性研究表明，短期暴露于抗生素与癌症风险增加无关。< </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-32409/'>《Helicobacter》</a> <b style="margin: 0 2px;">|</b><span>2019年第3期</span><b style="margin: 0 2px;">|</b><span>共6页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Okuda Masumi&option=202" target="_blank" rel="nofollow">Okuda Masumi;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lin Yingsong&option=202" target="_blank" rel="nofollow">Lin Yingsong;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wang Chaochen&option=202" target="_blank" rel="nofollow">Wang Chaochen;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kakiuchi Toshihiko&option=202" target="_blank" rel="nofollow">Kakiuchi Toshihiko;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kikuchi Shogo&option=202" target="_blank" rel="nofollow">Kikuchi Shogo;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of PediatricsAichi Medical University School of MedicineNagakute Japan;</p> <p>Department of Public HealthAichi Medical University School of MedicineNagakute Japan;</p> <p>Department of Public HealthAichi Medical University School of MedicineNagakute Japan;</p> <p>Department of Pediatrics Faculty of MedicineSaga UniversitySaga Japan;</p> <p>Department of Public HealthAichi Medical University School of MedicineNagakute Japan;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/183.html" title="微生物学">微生物学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=antimicrobial resistance&option=203" rel="nofollow">antimicrobial resistance;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=carcinogenicity&option=203" rel="nofollow">carcinogenicity;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=eradication&option=203" rel="nofollow">eradication;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Helicobacter pylori&option=203" rel="nofollow">Helicobacter pylori;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=metronidazole&option=203" rel="nofollow">metronidazole;</a> </p> <div class="translation"> 机译：抗微生物抗性;致癌性;根除;幽门螺杆菌;甲硝唑; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a 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href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=A A van Zwet&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">A A van Zwet,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=J C Thijs&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">J C Thijs,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=B de Graaf&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">B de Graaf </a> <span>1995</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：对于携带甲硝唑耐药的幽门螺杆菌菌株的患者使用甲硝唑进行三联疗法可根除率高。</span> </p> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/open-access_resources_thesis/0100099617400.html ">Triple therapy with clarithromycin, amoxicillin and omeprazole for Helicobacter pylori eradication in children and 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