The effect of intravenous administration of WEB 2086 on PAF-induced platelet aggregation in healthy Friesian calves.

摘要

The inhibitory activity of the specific platelet activating factor (PAF)-antagonist WEB 2086, a thienotriazolodiazepine, to inhibit PAF in cattle was investigated by determining platelet aggregation curves. Five healthy male Friesian calves were i.v. infused with WEB 2086 at 3 mg/kg over 1 min. The PAF inhibition peaked between 30 and 60 min after the administration. The inhibition was significantly reduced after 3 h and was insignificant after 6 h. However, maximum pre-treatment aggregation was restored by 24 h after the injection of WEB 2086. It is suggested that WEB 2086 is a potent antagonist of PAF activity in calves.