Single-Dose Interaction Study of the Arginine Vasopressin Type 1B Receptor Antagonist ABT-436 and Alcohol in Moderate Alcohol Drinkers

摘要

BackgroundABT-436, a potent and selective arginine vasopressin (AVP) type 1B receptor (V-1B) antagonist, has previously demonstrated basal hypothalamic-pituitary-adrenal (HPA) axis attenuation in man. A V-1B antagonist is hypothesized as an alcohol-dependent treatment based on the role of the V-1B receptor in stress regulation and the finding that stress is a trigger for relapse in alcoholics. A V-1B antagonist has shown favorable effects in rat models of alcohol dependence. A single-dose clinical study was conducted to assess the potential for pharmacokinetic or pharmacodynamic interaction between ABT-436 and alcohol.