In vitro metabolism of the anti-inflammatory clerodane diterpenoid polyandric acid A and its hydrolysis product by human liver microsomes and recombinant cytochrome P450 and UDP-glucuronosyltransferase enzymes

Bendikov Matthew Y.; Miners John O.; Simpson Bradley S.; Elliot David J.; Semple Susan J.; Claudie David J.; McKinnon Ross A.; Gillam Elizabeth M. J.; Sykes Matthew J.

首页> 外文期刊>Xenobiotica: the fate of foreign compounds in biological systems >In vitro metabolism of the anti-inflammatory clerodane diterpenoid polyandric acid A and its hydrolysis product by human liver microsomes and recombinant cytochrome P450 and UDP-glucuronosyltransferase enzymes

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In vitro metabolism of the anti-inflammatory clerodane diterpenoid polyandric acid A and its hydrolysis product by human liver microsomes and recombinant cytochrome P450 and UDP-glucuronosyltransferase enzymes

机译：通过人肝微粒体和重组细胞色素P450和UDP-葡糖醛糖基转移酶及其水解产物的体外代谢。及其水解产物及其水解产物

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1. The metabolism of the anti-inflammatory diterpenoid polyandric acid A (PAA), a constituent of the Australian Aboriginal medicinal plant Dodonaea polyandra, and its de-esterified alcohol metabolite, hydrolysed polyandric acid A (PAAH) was studied in vitro using human liver microsomes (HLM) and recombinant UDP-glucuronosyltransferase (UGT) and cytochrome P450 (CYP) enzymes.

机译：1.在体外使用人肝脏研究了澳大利亚土药植物Dodanaea Polyandra的抗炎二萜类金发酸A（PAA）的代谢，以及其去酯化的醇代谢物，水解的聚碳酸A（Paah）微粒体（HLM）和重组UDP-葡糖醛糖基转移酶（UGT）和细胞色素P450（CYP）酶。

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来源
《Xenobiotica: the fate of foreign compounds in biological systems》 |2017年第12期|共9页
作者
Bendikov Matthew Y.; Miners John O.; Simpson Bradley S.; Elliot David J.; Semple Susan J.; Claudie David J.; McKinnon Ross A.; Gillam Elizabeth M. J.; Sykes Matthew J.;
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作者单位

Flinders Univ S Australia Sch Med Dept Clin Pharmacol Adelaide SA Australia;

Flinders Univ S Australia Sch Med Dept Clin Pharmacol Adelaide SA Australia;

Flinders Univ S Australia Sch Med Flinders Ctr Innovat Canc Adelaide SA Australia;

Flinders Med Ctr Dept Clin Pharmacol Adelaide SA Australia;

Univ South Australia Sansom Inst Hlth Res Qual Use Med &

Pharm Res Ctr Adelaide SA Australia;

Chuulangun Aboriginal Corp Cairns Mail Ctr Cairns Australia;

Flinders Univ S Australia Sch Med Flinders Ctr Innovat Canc Adelaide SA Australia;

Univ Queensland Sch Chem &

Mol Biosci Brisbane Qld Australia;

Univ South Australia Sansom Inst Hlth Res Ctr Drug Discovery &

Dev Adelaide SA Australia;

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原文格式 PDF
正文语种 eng
中图分类毒物学（毒理学）;
关键词
Clerodane diterpenoid; cytochrome P450; esterases; glucuronidation; in vitro-in vivo extrapolation; polyandric acid A; reaction phenotyping; UDP-glucuronosyltransferase;

机译：clerodane diterpenoid;细胞色素p450;酯酶;葡萄糖醛酸;在体外外推;聚碳酸A;反应表型;UDP-葡糖醛糖基转移酶;

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1. In vitro metabolism of the anti-inflammatory clerodane diterpenoid polyandric acid A and its hydrolysis product by human liver microsomes and recombinant cytochrome P450 and UDP-glucuronosyltransferase enzymes [J] . Bendikov Matthew Y., Miners John O., Simpson Bradley S., Xenobiotica: the fate of foreign compounds in biological systems . 2017,第1a12期

机译：通过人肝微粒体和重组细胞色素P450和UDP-葡糖醛糖基转移酶及其水解产物的体外代谢。及其水解产物及其水解产物
2. Identification of cytochrome P450s involved in the metabolism of 6-benzyl-1-benzyloxymethyl-5-iodouracil (W-1) using human recombinant enzymes and rat liver microsomes in vitro [J] . Lu Ying-Yuan, Cheng Hai-Xu, Wang Xin, Xenobiotica: the fate of foreign compounds in biological systems . 2017,第1a12期

机译：在体外使用人重组酶和大鼠肝微粒体鉴定参与6-苄基-1-苄氧基甲氧基甲基-5-Iodouracil（W-1）的代谢的细胞色素P450s
3. Study of in vitro metabolism of m-oisoldipiee in human liver microsomes and recombinant cytochrome P450 enzymes by liquid chromatography-mass spectrometry [J] . Lin Yuan, Peipei Jia, Yupeng Sun, Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis . 2014,第Null期

机译：液相色谱-质谱法研究人肝微粒体中间-油溶二烯醚和重组细胞色素P450酶的体外代谢
4. Identification of Rilpivirine Metabolites in Human Liver Microsomes and Characterization of Cytochrome P450 Enzymes Involved in the Biotransformation by LC-MS/MS [C] . Josiane de Oliveira Cardoso, Jessica Bo Li Lu, Regina Vincenzi Oliveira, ASMS Conference on Mass Spectrometry and Allied Topics . 2014

机译：LC-MS / MS中，LC-MS / MS中患者肝脏微粒体中瑞培代谢产物的鉴定及涉及生物转化的细胞色素P450酶的表征
5. System-dependent metabolism of drugs by cytochrome P450: The mechanistic basis for why human liver microsomes are superior to human hepatocytes at metabolizing midazolam but inferior at metabolizing desloratadine [D] . Kazmi, Faraz 2015

机译：细胞色素P450对系统的药物依赖性代谢：为什么人肝微粒体在代谢咪达唑仑时要优于人肝细胞，而在地氯雷他定的代谢时却不如人肝细胞的机理基础
6. Characterization of the metabolism of fenretinide by human liver microsomes cytochrome P450 enzymes and UDP-glucuronosyltransferases [O] . NA Illingworth, AV Boddy, AK Daly, 2011

机译：人肝微粒体细胞色素P450酶和UDP-葡萄糖醛酸转移酶对芬维A胺代谢的表征
7. Characterization of the metabolism of fenretinide by human liver microsomes, cytochrome P450 enzymes and UDP-glucuronosyltransferases [O] . Illingworth, NA, Boddy, AV, Daly, AK, 2011

机译：人肝微粒体，细胞色素P450酶和UDP-葡萄糖醛酸转移酶对芬维A胺代谢的表征

In vitro metabolism of the anti-inflammatory clerodane diterpenoid polyandric acid A and its hydrolysis product by human liver microsomes and recombinant cytochrome P450 and UDP-glucuronosyltransferase enzymes

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