Target safety assessments and their role in de-risking drug discovery: NaV1.7 as an example

Eades Lauren; Sadler Claire; Knight Richard; Morton Michael; Roberts Ruth

首页> 外文期刊>Toxicology Letters: An International Journal Providing a Forum for Original and Pertinent Contributions in Toxicology Research >Target safety assessments and their role in de-risking drug discovery: NaV1.7 as an example

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Target safety assessments and their role in de-risking drug discovery: NaV1.7 as an example

机译：目标安全评估及其在失败的药物发现中的作用：Nav1.7作为一个例子

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《Toxicology Letters: An International Journal Providing a Forum for Original and Pertinent Contributions in Toxicology Research 》 |2017年第s1期| 共2页
作者
Eades Lauren; Sadler Claire; Knight Richard; Morton Michael; Roberts Ruth;
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ApconiX Alderley Edge England;

ApconiX Alderley Edge England;

ApconiX Alderley Edge England;

ApconiX Alderley Edge England;

ApconiX Alderley Edge England;

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原文格式 PDF
正文语种 eng
中图分类毒物学（毒理学） ;
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1. Target safety assessments and their role in de-risking drug discovery: NaV1.7 as an example [J] . Eades Lauren, Sadler Claire, Knight Richard, Toxicology Letters: An International Journal Providing a Forum for Original and Pertinent Contributions in Toxicology Research . 2017 ,第S1期

机译：目标安全评估及其在失败的药物发现中的作用：Nav1.7作为一个例子
2. Safety assessment considerations and strategies for targeted small molecule cancer therapeutics in drug discovery. [J] . Westhouse RA Toxicologic pathology . 2010 ,第1期

机译：药物发现中靶向小分子癌症治疗剂的安全性评估考虑和策略。
3. Applications of Dynamic Clamp to Cardiac Arrhythmia Research: Role in Drug Target Discovery and Safety Pharmacology Testing [J] . Francis A. Ortega, Eleonora Grandi, Trine Krogh-Madsen, Frontiers in Physiology . 2017 ,第12期

机译：动态钳位在心律失常研究中的应用：在药物目标发现和安全药理学测试中的作用
4. A Strategic Approach to Positioning of Cytochrome P450 Studies and Risk Assessment for Drug-Drug Interaction in Drug Discovery [C] . Yamada Yasuhiro International Conference on Cytochrome P450 . 2009

机译：细胞色素P450研究的战略方法，对药物发现中药物互动的研究和风险评估
5. Prioritizing Small Molecules for Drug Discovery or Chemical Safety Assessments using Ligand- and Structure-based Cheminformatics Approaches. [D] . Tang, Hao. 2011

机译：使用基于配体和结构的化学信息学方法对小分子进行药物发现或化学安全性评估的优先级。
6. Applications of Dynamic Clamp to Cardiac Arrhythmia Research: Role in Drug Target Discovery and Safety Pharmacology Testing [O] . Francis A. Ortega, Eleonora Grandi, Trine Krogh-Madsen, 2017

机译：动态钳夹在心律失常研究中的应用：在药物靶标发现和安全药理学测试中的作用
7. De-risking drug discovery of intracellular targeting peptides: screening strategies to eliminate false-positive hits [O] . Simon Ng, Yu-Chi Juang, Arun Chandramohan, 2019

机译：细胞内靶向肽的危险药物发现：筛选策略，以消除假阳性击球

Target safety assessments and their role in de-risking drug discovery: NaV1.7 as an example

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