Transient receptor potential melastatin 4 contributes to early-stage endothelial injury induced by arsenic trioxide

Yu Chun-Xiao; Zhang Yu-Yao; Wu Xia-Yang; Tang Hai-Xia; Liang Xue-Qi; Xue Zhou-Ming; Xue Ya-Dong; Li Jing; Zhu Hui; Huo Rong; Ban Tao

首页> 外文期刊>Toxicology Letters: An International Journal Providing a Forum for Original and Pertinent Contributions in Toxicology Research >Transient receptor potential melastatin 4 contributes to early-stage endothelial injury induced by arsenic trioxide

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Transient receptor potential melastatin 4 contributes to early-stage endothelial injury induced by arsenic trioxide

机译：瞬时受体潜在的素质素4有助于砷三氧化砷诱导的早期内皮损伤

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Background/aims: To investigate the effect of Arsenic Trioxide (ATO) on endothelial cells injury and explore the role of transient receptor potential melastatin 4 channel (TRPM4) in ATO-induced endothelial injury.

机译：背景/目的：探讨砷（ATO）对内皮细胞损伤的影响，探讨瞬态受体潜在蛋白酶素4通道（TRPM4）在ATO诱导的内皮损伤中的作用。

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来源
《Toxicology Letters: An International Journal Providing a Forum for Original and Pertinent Contributions in Toxicology Research》 |2019年第2019期|共11页
作者
Yu Chun-Xiao; Zhang Yu-Yao; Wu Xia-Yang; Tang Hai-Xia; Liang Xue-Qi; Xue Zhou-Ming; Xue Ya-Dong; Li Jing; Zhu Hui; Huo Rong; Ban Tao;
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作者单位

Harbin Med Univ State Prov Key Labs Biomed Pharmaceut China Key Lab Cardiovasc Res Dept;

Heilongjiang Univ Chinese Med Sch Basic Med Sci Dept Anat Histol &

Embryol Harbin Heilongjiang;

Fudan Univ Xiamen Childrens Hosp Xiamen Branch Childrens Hosp Xiamen Fujian Peoples R China;

Harbin Med Univ State Prov Key Labs Biomed Pharmaceut China Key Lab Cardiovasc Res Dept;

Harbin Med Univ State Prov Key Labs Biomed Pharmaceut China Key Lab Cardiovasc Res Dept;

Harbin Med Univ State Prov Key Labs Biomed Pharmaceut China Key Lab Cardiovasc Res Dept;

Harbin Med Univ State Prov Key Labs Biomed Pharmaceut China Key Lab Cardiovasc Res Dept;

Harbin Med Univ State Prov Key Labs Biomed Pharmaceut China Key Lab Cardiovasc Res Dept;

Harbin Med Univ Sch Basic Med Sci Dept Physiol Harbin Heilongjiang Peoples R China;

Harbin Med Univ State Prov Key Labs Biomed Pharmaceut China Key Lab Cardiovasc Res Dept;

Harbin Med Univ State Prov Key Labs Biomed Pharmaceut China Key Lab Cardiovasc Res Dept;

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原文格式 PDF
正文语种 eng
中图分类毒物学（毒理学）;
关键词
TRPM4; Endothelial injury; Arsenic trioxide; 9-phenanthrol; Human umbilical vein endothelial cells;

机译：TRPM4;内皮损伤;三氧化二砷;9-菲利尔;人脐静脉内皮细胞;

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专利

1. Transient receptor potential melastatin 4 contributes to early-stage endothelial injury induced by arsenic trioxide [J] . Yu Chun-Xiao, Zhang Yu-Yao, Wu Xia-Yang, Toxicology Letters: An International Journal Providing a Forum for Original and Pertinent Contributions in Toxicology Research . 2019,第期

机译：瞬时受体潜在的素质素4有助于砷三氧化砷诱导的早期内皮损伤
2. Transient receptor potential melastatin 7 (TRPM7) contributes to H 2O2-induced cardiac fibrosis via mediating Ca2+ influx and extracellular signal-regulated kinase 1/2 (ERK1/2) activation in cardiac fibroblasts [J] . GuoJ.-L., YuY., JiaY.-Y., Journal of pharmacological sciences. . 2014,第2期

机译：瞬时受体电位褪黑素7（TRPM7）通过介导心脏成纤维细胞中的Ca2 +内流和细胞外信号调节激酶1/2（ERK1 / 2）活化，促进H 2O2诱导的心脏纤维化。
3. Transient Receptor Potential Melastatin 7 (TRPM7) Contributes to H2O2-Induced Cardiac Fibrosis via Mediating Ca2+ Influx and Extracellular Signal–Regulated Kinase 1/2 (ERK1/2) Activation in Cardiac Fibroblasts [J] . Bo-Yu Zhang, Jian-Min Jiang, Jin-Lei Guo, Journal of pharmacological sciences. . 2014,第2期

机译：瞬态受体潜在的褪黑素7（TRPM7）通过介导心脏成纤维细胞中的Ca2 +流入和细胞外信号调节的激酶1/2（ERK1 / 2）活化，促进H2O2诱导的心脏纤维化。
4. Vascular Endothelial Growth Factor Is a Target Gene for Estrogen Receptor and Contributes to Breast Cancer Progression [C] . Martine Perrot Applanat, Helene Buteau-Lozano, Marie Astrid Herve, International Symposium on Hormonal Carcinogenesis . 2008

机译：血管内皮生长因子是雌激素受体的靶基因，有助于乳腺癌进展
5. The Effect of Aflatoxin B1 Treatment on Transient Receptor Potential Melastatin 8 Expression in Gonadal Cells [D] . Boss, Kristina. 2020

机译：黄曲霉毒素B1治疗对瞬时受体潜在素母酸素8在促性腺细胞中表达的影响
6. Transient Receptor Potential Melastatin 4 Induces Astrocyte Swelling But Not Death after Diffuse Traumatic Brain Injury [O] . Karen M. Gorse, Mary Kate Lantzy, Eun D. Lee, -1

机译：弥漫性颅脑损伤后瞬时受体潜在的melastatin 4诱导星形胶质细胞肿胀但未导致死亡。
7. Transient Receptor Potential Melastatin 4 (TRPM4) Contributes to High Salt Diet-Mediated Early-Stage Endothelial Injury [O] . Xiao-Qing Ding, Tao Ban, Zeng-Yan Liu, 2017

机译：瞬时受体电位melastatin 4（TRpm4）有助于高盐饮食介导的早期内皮细胞损伤

Transient receptor potential melastatin 4 contributes to early-stage endothelial injury induced by arsenic trioxide

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