To analyze HIV-1 subtype distribution, sequence analysis was performed on serum specimens obtained in 1994 from the Rakai Health Sciences community cohort in Uganda. Portions of gag-p24 and env-gp41 were sequenced and HIV subtype was determined for 773 subjects residing in 10 community clusters in rural Uganda. Subtypes A (17%) and D (70%) were the most common strains in the population. Subtype distribution varied by geographic region with significantly more subtype A in northern community clusters compared with southern clusters (21% vs. 8%, p < 0.001) and more subtype D in southern clusters compared with northern clusters (78% vs. 65%, p < 0.008). These data illustrate the geographic complexity of subtype variation, which has important implications for HIV-1 vaccine design.
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机译：为了分析HIV-1亚型的分布，对1994年从乌干达的Rakai Health Sciences社区队列获得的血清标本进行了序列分析。对gag-p24和env-gp41的部分进行了测序，并确定了乌干达农村地区10个社区中的773名受试者的HIV亚型。亚型A（17％）和D（70％）是种群中最常见的菌株。亚型分布随地理区域的变化而变化，北部群落群中的亚型A明显高于南部群（21％vs. 8％，p <0.001），而南部群中的D亚型则比北部群（78％vs. 65％）多。 p <0.008）。这些数据说明了亚型变异的地理复杂性，这对HIV-1疫苗设计具有重要意义。
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