Pleiotropic effects of n-6 and n-3 fatty acid-related genetic variants on circulating hemostatic variables

Weng Lu-Chen; Guan Weihua; Steffen Lyn M.; Pankow James S.; Pankratz Nathan; Chen Ming-Huei; Cushman Mary; Basu Saonli; Folsom Aaron R.; Tang Weihong

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Pleiotropic effects of n-6 and n-3 fatty acid-related genetic variants on circulating hemostatic variables

机译：N-6和N-3脂肪酸相关遗传变异对循环止血变量的脂肪效应

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Introduction: Data from epidemiological studies and clinical trials suggest an influence of dietary and circulating polyunsaturated fatty acids (PUFAs) on the hemostasis profile. Genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) related to plasma PUFAs levels. We aimed to investigate whether the SNPs related to plasma PUFAs levels were also associated with plasma levels of hemostatic variables.

机译：简介：流行病学研究和临床试验的数据表明膳食和循环多不饱和脂肪酸（PUFAs）对止血型材的影响。基因组 - 范围的协会研究（GWAs）鉴定了与血浆PUFA水平相关的单核苷酸多态性（SNP）。我们旨在探讨与血浆PUFA水平相关的SNP是否也与止血变量的血浆水平相关。

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来源
《Thrombosis Research: An International Journal on Vascular Obstruction, Hemorrhage and Hemostasis》 |2018年第2018期|共7页
作者
Weng Lu-Chen; Guan Weihua; Steffen Lyn M.; Pankow James S.; Pankratz Nathan; Chen Ming-Huei; Cushman Mary; Basu Saonli; Folsom Aaron R.; Tang Weihong;
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作者单位

Univ Minnesota Div Epidemiol &

Community Hlth Sch Publ Hlth 1300 South Second St WBOB 300;

Univ Minnesota Sch Publ Hlth Div Biostat 420 Delaware St SE Minneapolis MN 55455 USA;

Univ Minnesota Div Epidemiol &

Community Hlth Sch Publ Hlth 1300 South Second St WBOB 300;

Univ Minnesota Div Epidemiol &

Community Hlth Sch Publ Hlth 1300 South Second St WBOB 300;

Univ Minnesota Dept Lab Med &

Pathol Sch Med Mayo Mail Code 609 420 Delaware St SE Minneapolis;

NHLBI Framingham Heart Study Populat Sci Branch Div Intramural Res Framingham MA USA;

Univ Vermont Dept Med Colchester Res Facil 360 South Pk Dr Colchester VT 05446 USA;

Univ Minnesota Sch Publ Hlth Div Biostat 420 Delaware St SE Minneapolis MN 55455 USA;

Univ Minnesota Div Epidemiol &

Community Hlth Sch Publ Hlth 1300 South Second St WBOB 300;

Univ Minnesota Div Epidemiol &

Community Hlth Sch Publ Hlth 1300 South Second St WBOB 300;

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正文语种 eng
中图分类神经病学;
关键词
Hemostatic variables; Polyunsaturated fatty acids; Single nucleotide polymorphism; Genetic pleiotropy;

机译：止血变量;多不饱和脂肪酸;单核苷酸多态性;遗传胸膜;

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专利

1. Pleiotropic effects of n-6 and n-3 fatty acid-related genetic variants on circulating hemostatic variables [J] . Weng Lu-Chen, Guan Weihua, Steffen Lyn M., Thrombosis Research: An International Journal on Vascular Obstruction, Hemorrhage and Hemostasis . 2018,第期

机译：N-6和N-3脂肪酸相关遗传变异对循环止血变量的脂肪效应
2. Genetic Variants of the FADS1 FADS2 Gene Cluster Are Associated with Altered (n-6) and (n-3) Essential Fatty Acids in Plasma and Erythrocyte Phospholipids in Women during Pregnancy and in Breast Milk during Lactation [J] . Lin Xie3, Sheila M. Innis4* The Journal of Nutrition: Official Organ of the American Institute of Nutrition . 2008,第11期

机译：FADS1 FADS2基因簇的遗传变异与孕妇和哺乳期母乳中血浆和红细胞磷脂中的（n-6）和（n-3）必需脂肪酸改变有关
3. The combined effects of genetic variation in the SIRT1 gene and dietary intake of n-3 and n-6 polyunsaturated fatty acids on serum LDL-C and HDL-C levels: a population based study [J] . Tomoko Inamori, Toshinao Goda, Nobuhiko Kasezawa, Lipids in Health Disease . 2013,第3期

机译：SIRT1基因遗传变异与膳食摄入n-3和n-6多不饱和脂肪酸对血清LDL-C和HDL-C水平的综合影响：一项基于人群的研究
4. An Experimental Study of the Effects of Various proportioned n-3 Series and n-6 Series Polyunsaturated Fatty Acid Oils on Metabolism in vivo [C] . Essential Fatty Acids and Human Nutrition and Health International Conference: Symposium Proceedings Apr, 2002 Shanghai, P.R.China . 2002

机译：不同比例的n-3系列和n-6系列多不饱和脂肪酸油对体内代谢影响的实验研究
5. Effects of n-3 and n-6 polyunsaturated fatty acids on human promyelocytic HL-60 cells. [D] . Gillis, Robert Clements. 2003

机译：n-3和n-6多不饱和脂肪酸对人早幼粒细胞HL-60细胞的影响。
6. Pleiotropic Effects of n-6 and n-3 Fatty Acid-Related GeneticVariants on Circulating Hemostatic Variables [O] . Lu-Chen Weng, Weihua Guan, Lyn M. Steffen, -1

机译：n-6和n-3脂肪酸相关遗传的多效性效应循环止血变量的变体
7. Pleiotropic effects of n-6 and n-3 fatty acid-related genetic variants on circulating hemostatic variables [O] . Lu-Chen Weng, Weihua Guan, Lyn M. Steffen, 2018

机译：N-6和N-3脂肪酸相关遗传变异对循环止血变量的抗脂肪效应

Pleiotropic effects of n-6 and n-3 fatty acid-related genetic variants on circulating hemostatic variables

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