Pharmacokinetics and Pharmacodynamics of Once-Daily Tacrolimus Compared With Twice-Daily Tacrolimus in the Early Stage After Living Donor Liver Transplantation

Iwasaki Mami; Yano Ikuko; Fukatsu Sachio; Hashi Sachiyo; Yamamoto Yuki; Sugimoto Mitsuhiro; Fukudo Masahide; Masuda Satohiro; Nakagawa Shunsaku; Yonezawa Atsushi; Kaido Toshimi; Uemoto Shinji; Matsubara Kazuo

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Pharmacokinetics and Pharmacodynamics of Once-Daily Tacrolimus Compared With Twice-Daily Tacrolimus in the Early Stage After Living Donor Liver Transplantation

机译：曾经每日躯干司的药代动力学和药效动物与早期肝脏移植后早期的每次Tacrolimus相比

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Background: This study investigates the pharmacokinetics and pharmacodynamics of tacrolimus using the once-daily (OD) formulation in the early stage after living donor liver transplantation (LDLT) in comparison with those using the twice-daily (TD) formulation.

机译：背景：本研究研究了与使用两次每日（Td）制剂的人相比，在早期的早期阶段使用曾经（OD）制剂，研究了他克莫司的药代动力学和药效学。

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来源
《Therapeutic Drug Monitoring》 |2018年第6期|共7页
作者
Iwasaki Mami; Yano Ikuko; Fukatsu Sachio; Hashi Sachiyo; Yamamoto Yuki; Sugimoto Mitsuhiro; Fukudo Masahide; Masuda Satohiro; Nakagawa Shunsaku; Yonezawa Atsushi; Kaido Toshimi; Uemoto Shinji; Matsubara Kazuo;
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作者单位

Kyoto Univ Hosp Dept Clin Pharmacol &

Therapeut Kyoto Japan;

Kyoto Univ Hosp Dept Clin Pharmacol &

Therapeut Kyoto Japan;

Kyoto Univ Hosp Dept Clin Pharmacol &

Therapeut Kyoto Japan;

Kyoto Univ Hosp Dept Clin Pharmacol &

Therapeut Kyoto Japan;

Kyoto Univ Hosp Dept Clin Pharmacol &

Therapeut Kyoto Japan;

Kyoto Univ Hosp Dept Clin Pharmacol &

Therapeut Kyoto Japan;

Kyoto Univ Hosp Dept Clin Pharmacol &

Therapeut Kyoto Japan;

Kyoto Univ Hosp Dept Clin Pharmacol &

Therapeut Kyoto Japan;

Kyoto Univ Hosp Dept Clin Pharmacol &

Therapeut Kyoto Japan;

Kyoto Univ Hosp Dept Clin Pharmacol &

Therapeut Kyoto Japan;

Kyoto Univ Grad Sch Med Div Hepatobiliary Pancreat Surg &

Transplantat Dept Surg Kyoto Japan;

Kyoto Univ Grad Sch Med Div Hepatobiliary Pancreat Surg &

Transplantat Dept Surg Kyoto Japan;

Kyoto Univ Hosp Dept Clin Pharmacol &

Therapeut Kyoto Japan;

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原文格式 PDF
正文语种 eng
中图分类生药学（天然药物学）;
关键词
tacrolimus; LDLT; OD; pharmacokinetics; calcineurin activity;

机译：Tacrolimus;LDLT;OD;药代动力学;钙碱活动;

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专利

1. Pharmacokinetics and Pharmacodynamics of Once-Daily Tacrolimus Compared With Twice-Daily Tacrolimus in the Early Stage After Living Donor Liver Transplantation [J] . Iwasaki Mami, Yano Ikuko, Fukatsu Sachio, Therapeutic Drug Monitoring . 2018,第6期

机译：曾经每日躯干司的药代动力学和药效动物与早期肝脏移植后早期的每次Tacrolimus相比
2. Once-daily, prolonged-release tacrolimus vs twice-daily, immediate-release tacrolimus in de novo living-donor liver transplantation: A Phase 4, randomized, open-label comparative, single-center study [J] . Shin Min-Ho, Song Gi-Won, Lee Sung-Gyu, Clinical transplantation. . 2018,第9期

机译：每日一日，延长释放的Tacrolimus vs两次每日，即时释放的Tacrolimus在Novo Live-供体肝移植中：一个第4期，随机，开放标签比较，单中心研究
3. Pilot Study Comparing the Efficacy, Safety, Convertibility, and Tacrolimus Trough Levels of Twice-Daily Tacrolimus (Prograf) to Once-Daily Tacrolimus (Advagraf) Among Standard-Risk Kidney Transplant Patients at the National Kidney and Transplant Institute [J] . Danguilan Romina A., Lamban Arlene, Pamugas Glenda Eleanor P. Transplantation Proceedings . 2019,第8期

机译：试点研究将两次Tacrolimus（Prograf）的疗效，安全性，可转化性和他克莫司槽水平与国家肾脏和移植研究所的标准风险性肾移植患者中的一次每日他克莫司（Advagraf）进行比较
4. ASSOCIATION OF CYP3A4 * 18B POLYMORPHISMS WITH THE PHARMACOKINETICS OF TACROLIMUS IN CHINESE RENAL TRANSPLANT RECIPIENTS [C] . Li Danying, Fang Yun, Teng Ruichen Progress on post-genome technologies and modern natural products . 2011

机译：CYP3A4 * 18B多态性与中国肾移植患者滑石M药代动力学的关系
5. Effect of diabetes mellitus on pharmacokinetics and pharmacodynamics of tacrolimus and sirolimus [D] . Chitnis, Shripad D. 2012

机译：糖尿病对他克莫司和西罗莫司药代动力学和药效学的影响
6. Pharmacokinetics of tacrolimus converted from twice-daily formulation to once-daily formulation in Chinese stable liver transplant recipients [O] . Yi-fan Zhang, Xiao-yan Chen, Xiao-jian Dai, 2011

机译：他克莫司在中国稳定的肝移植受者中的药代动力学从每日两次转换为每日一次
7. Pharmacokinetics for once-daily versus twice-daily tacrolimus formulations in de novo liver transplantation: a randomized, open-label trial. [O] . Fischer, Lutz, Trunečka, Pavel, Gridelli, Bruno, 2011

机译：从头肝移植中每天一次他克莫司与每天两次他克莫司制剂的药代动力学：一项随机，开放标签的试验。

Pharmacokinetics and Pharmacodynamics of Once-Daily Tacrolimus Compared With Twice-Daily Tacrolimus in the Early Stage After Living Donor Liver Transplantation

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