Serum alpha(1)-proteinase inhibitor concentrations in dogs with exocrine pancreatic disease, chronic hepatitis or proteinuric chronic kidney disease

摘要

Serum canine alpha(1)-proteinase inhibitor (c alpha(1)-PI) concentrations were evaluated in dogs with pancreatitis (n = 24), exocrine pancreatic insufficiency (EPI; n = 29), chronic hepatitis (CH; n=11) or proteinuric chronic kidney disease (CKD-P; n = 61) to determine whether systemic proteinase/proteinase-inhibitor balance is altered in these conditions. Dogs with CKD-P had significantly lower cal-PI concentrations than dogs with pancreatitis, EPI or CH; 16% of dogs with CKD-P had serum cal-PI concentrations below the reference interval. Serum and urine cost-PI concentrations were inversely correlated in dogs with CKD-P, but not in dogs with CH. This suggests that renal loss of cat-PI contributes to decreased serum concentrations in dogs with CKD-P, while hepatic c(alpha 1)-PI synthesis with CH either is not compromised or is counterbalanced by extrahepatic production. (C) 2018 Elsevier Ltd. All rights reserved.