New pharmacokinetic/pharmacodynamic studies of systemically administered colistin against Pseudomonas aeruginosa and Acinetobacter baumannii in mouse thigh and lung infection models: smaller response in lung infection

Cheah Soon-Ee; Wang Jiping; Van Thi Thu Nguyen; Turnidge John D.; Li Jian; Nation Roger L.

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New pharmacokinetic/pharmacodynamic studies of systemically administered colistin against Pseudomonas aeruginosa and Acinetobacter baumannii in mouse thigh and lung infection models: smaller response in lung infection

机译：对小鼠大腿和肺部感染模型进行全系统施用Colistin的新药代动力学/药效学研究，肺部感染模型：肺部感染的较小反应

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Objectives: This study investigated the exposure-response relationships between unbound colistin in plasma and antibacterial activity in mouse thigh and lung infections.

机译：目的：本研究研究了小鼠大腿和肺部感染中血浆血浆和抗菌活性的未结肠蛋白的暴露 - 反应关系。

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《The Journal of Antimicrobial Chemotherapy》 |2015年第12期|共7页
作者
Cheah Soon-Ee; Wang Jiping; Van Thi Thu Nguyen; Turnidge John D.; Li Jian; Nation Roger L.;
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Monash Univ Monash Inst Pharmaceut Sci Drug Delivery Disposit &

Dynam Parkville Vic 3052;

Monash Univ Monash Inst Pharmaceut Sci Drug Delivery Disposit &

Dynam Parkville Vic 3052;

Monash Univ Monash Inst Pharmaceut Sci Drug Delivery Disposit &

Dynam Parkville Vic 3052;

Univ Adelaide Dept Pathol Adelaide SA 5005 Australia;

Monash Univ Monash Inst Pharmaceut Sci Drug Delivery Disposit &

Dynam Parkville Vic 3052;

Monash Univ Monash Inst Pharmaceut Sci Drug Delivery Disposit &

Dynam Parkville Vic 3052;

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正文语种 eng
中图分类治疗学;
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1. New pharmacokinetic/pharmacodynamic studies of systemically administered colistin against Pseudomonas aeruginosa and Acinetobacter baumannii in mouse thigh and lung infection models: smaller response in lung infection [J] . Cheah Soon-Ee, Wang Jiping, Van Thi Thu Nguyen, The Journal of Antimicrobial Chemotherapy . 2015,第12期

机译：对小鼠大腿和肺部感染模型进行全系统施用Colistin的新药代动力学/药效学研究，肺部感染模型：肺部感染的较小反应
2. fAUC/MIC is the most predictive pharmacokinetic/pharmacodynamic index of colistin against Acinetobacter baumannii in murine thigh and lung infection models. [J] . Dudhani RV, Turnidge JD, Nation RL, The Journal of Antimicrobial Chemotherapy . 2010,第9期

机译：在鼠大腿和肺部感染模型中，fAUC / MIC是大肠菌素对鲍曼不动杆菌的最可预测的药代动力学/药效学指标。
3. Elucidation of the pharmacokinetic/pharmacodynamic determinant of colistin activity against Pseudomonas aeruginosa in murine thigh and lung infection models. [J] . Dudhani RV, Turnidge JD, Coulthard Antimicrobial agents and chemotherapy. . 2010,第3期

机译：阐明在鼠大腿和肺部感染模型中大肠菌素对铜绿假单胞菌活性的药代动力学/药效学决定因素。
4. Antimicrobial photodynamic therapy in a mouse model of Acinetobacter baumannii burn infection [C] . Tianhong Dai, George P Tegos, Zongshun Lu, World congress of the International Photodynamic Association . 2009

机译：鲍曼不动杆菌烧伤感染小鼠模型的抗菌光动力疗法
5. Study of virulence factors associated with Acinetobacter baumannii systemic and gastrointestinal infections. [D] . Ketter, Patrick Morgan. 2015

机译：研究鲍曼不动杆菌与全身和胃肠道感染有关的毒力因子。
6. fAUC/MIC is the most predictive pharmacokinetic/pharmacodynamic index of colistin against Acinetobacter baumannii in murine thigh and lung infection models [O] . Rajesh V. Dudhani, John D. Turnidge, Roger L. Nation, -1

机译：在鼠大腿和肺部感染模型中fAUC / MIC是大肠菌素对鲍曼不动杆菌的最具预测性的药代动力学/药效学指标
7. fAUC/MIC is the most predictive pharmacokinetic/pharmacodynamic index of colistin against Acinetobacter baumannii in murine thigh and lung infection models [O] . Dudhani, Rajesh V., Turnidge, John D., Nation, Roger L., 2010

机译：在鼠大腿和肺部感染模型中，fAUC / MIC是大肠菌素对鲍曼不动杆菌的最可预测的药代动力学/药效学指标

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New pharmacokinetic/pharmacodynamic studies of systemically administered colistin against Pseudomonas aeruginosa and Acinetobacter baumannii in mouse thigh and lung infection models: smaller response in lung infection

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