Transgenic mouse lung tissue specifically expressing human DPP4 gene susceptible for South Korean strain Middle East respiratory syndrome coronavirus infection and use thereof

摘要

The present invention relates to a transgenic mouse expressing the human Dipeptidyl peptidase 4 (human DPP4, hDPP4) gene, which is a coronavirus infection receptor for Middle East Respiratory Syndrome, specifically for lung tissue, and more specifically, an SPB promoter; Human DPP4 gene; And it relates to a transgenic mouse for expressing the human DPP4 gene, transformed with a recombinant vector for expressing the human DPP4 gene operably linked by tagging a Flag peptide at the C-terminal region, and a method of producing the transgenic mouse. . Transgenic mice expressing human DPP4 gene lung tissue-specific according to the present invention can be used as an important animal model for in vivo studies to identify the development of coronavirus infectious diseases of Middle East Respiratory Syndrome, and vaccine for controlling Middle East Respiratory Syndrome coronavirus. And it can be used very usefully in the development of therapeutic agents.