Low pH reduces the activity of ceftolozane/tazobactam in human urine, but confirms current breakpoints for urinary tract infections

Nussbaumer-Proell Alina Karoline; Eberl Sabine; Reiter Birgit; Stimpfl Thomas; Dorn Christoph; Zeitlinger Markus

首页> 外文期刊>The Journal of Antimicrobial Chemotherapy >Low pH reduces the activity of ceftolozane/tazobactam in human urine, but confirms current breakpoints for urinary tract infections

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Low pH reduces the activity of ceftolozane/tazobactam in human urine, but confirms current breakpoints for urinary tract infections

机译：低pH降低了猪甲基甲烷/塔扎酰胺在人尿中的活性，但确认了尿路感染的当前断裂点

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Background: Acidic pH has been shown to impact the antibiotic activity of non-beta-lactams in urine.

机译：背景：已显示酸性pH以影响尿液中非β-内酰胺的抗生素活性。

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来源
《The Journal of Antimicrobial Chemotherapy》 |2020年第3期|共7页
作者
Nussbaumer-Proell Alina Karoline; Eberl Sabine; Reiter Birgit; Stimpfl Thomas; Dorn Christoph; Zeitlinger Markus;
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作者单位

Med Univ Vienna Dept Clin Pharmacol Vienna Austria;

Med Univ Vienna Dept Clin Pharmacol Vienna Austria;

Med Univ Vienna Clin Dept Med &

Chem Lab Diagnost Vienna Austria;

Med Univ Vienna Clin Dept Med &

Chem Lab Diagnost Vienna Austria;

Univ Regensburg Inst Pharm Regensburg Germany;

Med Univ Vienna Dept Clin Pharmacol Vienna Austria;

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正文语种 eng
中图分类治疗学;
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1. Low pH reduces the activity of ceftolozane/tazobactam in human urine, but confirms current breakpoints for urinary tract infections [J] . Nussbaumer-Proell Alina Karoline, Eberl Sabine, Reiter Birgit, The Journal of Antimicrobial Chemotherapy . 2020,第3期

机译：低pH降低了猪甲基甲烷/塔扎酰胺在人尿中的活性，但确认了尿路感染的当前断裂点
2. Ceftolozane/tazobactam activity against drug-resistant Enterobacteriaceae and Pseudomonas aeruginosa causing urinary tract and intraabdominal infections in Europe: report from an antimicrobial surveillance programme (2012-15) [J] . Pfaller Michael A., Bassetti Matteo, Duncan Leonard R., The Journal of Antimicrobial Chemotherapy . 2017,第5期

机译：抗毒药肠杆菌和铜绿假西亚岛和铜绿假单胞菌的头孢噻唑胺活性导致欧洲尿路和肿瘤腹部感染：抗菌监测计划（2012-15）的报告
3. Ceftolozane/tazobactam activity tested against aerobic Gram-negative organisms isolated from intra-abdominal and urinary tract infections in European and United States hospitals (2012). [J] . Helio S Sader, David J Farrell, Robert K Flamm, Journal of Infection . 2014,第3期

机译：在欧洲和美国的医院中，对从腹部内和尿路感染中分离出来的好氧革兰氏阴性菌测试了头孢洛赞/他唑巴坦活性（2012年）。
4. Identification of potential metabolic biomarkers of lower urinary tract symptoms (LUTS) in mouse and human urines via UPLC-ESI-MS [C] . Ling Hao, Tyler Greer, Chad Vezina, ASMS Conference on Mass Spectrometry and Allied Topics . 2014

机译：通过UPLC-ESI-MS鉴定小鼠和人类尿液中低尿路症状（LUTS）的潜在代谢生物标志物
5. The Study of Special Urogynecologic Topics Related to the Pelvic Floor and Lower Urinary Tract: A Focus on Recurrent Urinary Tract Infections Between Two Cohorts of Women & the Assessment of Women's Reluctance to Use Topical Vaginal Estrogen [D] . Dune, Tanaka Junior. 2019

机译：关于盆腔楼层和低尿路相关的特殊辅音学主题研究：对妇女两组队队之间的复发性尿路感染的关注，妇女不愿意使用局部阴道雌激素的评估
6. 1436. Comparison of Ceftazidime–Avibactam Ceftolozane–Tazobactam Piperacillin–Tazobactam and Meropenem Activities When Tested Against Gram-Negative Organisms Isolated From Complicated Urinary Tract Infections [O] . Helio S Sader, Robert K Flamm, Mariana Castanheira, -1

机译：1436.头孢他啶-阿维巴坦头孢洛氮烷-他唑巴坦哌拉西林-他唑巴坦和美罗培南活性的比较针对从复杂的尿路感染中分离出来的革兰氏阴性菌进行了测试
7. 1436. Comparison of Ceftazidime–Avibactam, Ceftolozane–Tazobactam, Piperacillin–Tazobactam, and Meropenem Activities When Tested Against Gram-Negative Organisms Isolated From Complicated Urinary Tract Infections [O] . Helio S Sader, Robert K Flamm, Mariana Castanheira, 2019

机译：1436.在用复杂的尿路感染分离的革兰氏阴性生物测试时，CeTtazidime-Avibactam，Ceftolozane-Tazobactam，Piberacillin-Tazobactam和Meropenem活动的比较

Low pH reduces the activity of ceftolozane/tazobactam in human urine, but confirms current breakpoints for urinary tract infections

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