HOMOGRAFT VERSUS CONVENTIONAL PROSTHESIS FOR SURGICAL MANAGEMENT OF AORTIC VALVE INFECTIVE ENDOCARDITIS A SYSTEMATIC REVIEW AND META-ANALYSIS

摘要

BACKGROUND: There is equipoise with regards to the optimal prosthesis for aortic valve infective endocarditis (IE). A systematic review and meta-analysis was performed to compare outcomes between homograft and conventional prosthesis for aortic valve IE. METHODS AND RESULTS: We searched MEDLINE and EMBASE databases from 1946-2016 for studies comparing homograft versus conventional prosthesis. The main outcomes were all-cause mortality, recurrent IE and reopera-tion. There were 18 included studies with 2232 patients (median follow up 5 [inter-quartile range: 2-7] years, 30% prosthetic valve endocarditis); four studies were adjusted for baseline differences. There were no differences in peri-operative mortality or stroke despite a greater proportion of staphylococcal endocarditis, abscess, and root replacements but less multivalve involvement in the homograft group.