Efficacy and safety of inhaled alpha 1-antitrypsin in patients with severe alpha 1-antitrypsin deficiency and frequent exacerbations of COPD

Stolk Jan; Tov Naveh; Chapman Kenneth R.; Fernandez Pablo; MacNee William; Hopkinson Nicholas S.; Piitulainen Eeva; Seersholm Niels; Vogelmeier Claus F.; Bals Robert; McElvaney Gerry; Stockley Robert A.

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Efficacy and safety of inhaled alpha 1-antitrypsin in patients with severe alpha 1-antitrypsin deficiency and frequent exacerbations of COPD

机译：吸入α1-抗抗胰蛋白酶在严重α1-抗胰蛋白酶缺乏症患者中的疗效和安全性和频繁加剧COPD

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Patients with inherited alpha 1-antitrypsin (AAT) deficiency (ZZ-AATD) and severe chronic obstructive pulmonary disease (COPD) frequently experience exacerbations. We postulated that inhalation of nebulised AAT would be an effective treatment.

机译：患有α1-抗酸胆蛋白（AAT）缺乏（ZZ-AATD）和严重的慢性阻塞性肺病（COPD）的患者经常经历加剧。我们假设吸入雾化AAT是一种有效的治疗方法。

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《The European respiratory journal :》 |2019年第5期|共10页
作者
Stolk Jan; Tov Naveh; Chapman Kenneth R.; Fernandez Pablo; MacNee William; Hopkinson Nicholas S.; Piitulainen Eeva; Seersholm Niels; Vogelmeier Claus F.; Bals Robert; McElvaney Gerry; Stockley Robert A.;
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作者单位

Leiden Univ Med Ctr Dept Pulmonol European Reference Network LUNG Leiden Netherlands;

Kamada Ltd Dept Clin Dev Rehovot Israel;

Univ Toronto Dept Med Toronto ON Canada;

Univ Edinburgh Edinburgh Midlothian Scotland;

Imperial Coll London Natl Heart &

Lung Inst London England;

Lund Univ Dept Resp Med &

Allergol Skane Univ Hosp Lund Sweden;

Gentofte Univ Hosp Dept Resp Med Y Copenhagen Denmark;

Philipps Univ Marburg Dept Med Pulm &

Crit Care Med German Ctr Lung Dis DZL Univ Med Ctr Giessen;

Hosp Univ Saarland Internal Med Pulmonol 5 German Ctr Lung Dis DZL Homburg Germany;

Royal Coll Surgeons Ireland Dept Resp Med Beaumont Hosp Dublin Ireland;

Queen Elizabeth Hosp Birmingham W Midlands England;

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正文语种 eng
中图分类呼吸系及胸部疾病;
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1. Efficacy and safety of inhaled alpha 1-antitrypsin in patients with severe alpha 1-antitrypsin deficiency and frequent exacerbations of COPD [J] . Stolk Jan, Tov Naveh, Chapman Kenneth R., The European respiratory journal : . 2019,第5期

机译：吸入α1-抗抗胰蛋白酶在严重α1-抗胰蛋白酶缺乏症患者中的疗效和安全性和频繁加剧COPD
2. Plasma levels of alpha1-antichymotrypsin and secretory leukocyte proteinase inhibitor in healthy and chronic obstructive pulmonary disease (COPD) subjects with and without severe α1-antitrypsin deficiency [J] . Camilla Hollander, Ulla Westin, Anders Wallmark, BMC Pulmonary Medicine . 2007,第1期

机译：在患有和不患有严重的α1-抗胰蛋白酶缺乏症的健康和慢性阻塞性肺疾病（COPD）患者中，血浆α1-抗胰凝乳蛋白酶和分泌型白细胞蛋白酶抑制剂的水平
3. Discrimination between COPD patients with and without alpha 1-antitrypsin deficiency using an electronic nose. [J] . Hattesohl AD, Jorres RA, Dressel H, Respirology : . 2011,第8期

机译：使用电子鼻对患有和不患有α1-抗胰蛋白酶缺乏症的COPD患者进行区分。
4. Beating Alpha 1-antitrypsin: a novel quantitative analysis in High Resolution Mass Spectrometry [C] . Luca Genovesi, Luca Barbero, Luigi Colombo American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2012

机译：敲打α1-抗抗酸酯：高分辨率质谱中的新量分析
5. Adult stem cell-based gene therapy for alpha 1-antitrypsin deficiency [D] . Li, Hong 2009

机译：基于成人干细胞的基因治疗α1-抗胰蛋白酶缺乏症
6. Plasma levels of alpha1-antichymotrypsin and secretory leukocyte proteinase inhibitor in healthy and chronic obstructive pulmonary disease (COPD) subjects with and without severe α1-antitrypsin deficiency [O] . Camilla Hollander, Ulla Westin, Anders Wallmark, 2007

机译：在患有和不患有严重的α1-抗胰蛋白酶缺乏症的健康和慢性阻塞性肺病（COPD）患者中血浆α1-抗胰凝乳蛋白酶和分泌型白细胞蛋白酶抑制剂的水平
7. Plasma levels of alpha1-antichymotrypsin and secretory leukocyte proteinase inhibitor in healthy and chronic obstructive pulmonary disease (COPD) subjects with and without severe α1-antitrypsin deficiency [O] . Camilla Hollander, Ulla Westin, Anders Wallmark, 2007

机译：在患有和不患有严重的α1-抗胰蛋白酶缺乏症的健康和慢性阻塞性肺病（COPD）患者中，血浆α1-抗胰凝乳蛋白酶和分泌型白细胞蛋白酶抑制剂的水平

Efficacy and safety of inhaled alpha 1-antitrypsin in patients with severe alpha 1-antitrypsin deficiency and frequent exacerbations of COPD

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