MicroRNA-574-5p directly targets FOXN3 to mediate thyroid cancer progression via Wnt/beta-catenin signaling pathway

Zhang Zhe-Jia; Xiao Qian; Li Xin-Ying

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MicroRNA-574-5p directly targets FOXN3 to mediate thyroid cancer progression via Wnt/beta-catenin signaling pathway

机译：MicroRNA-574-5P直接靶向FOXN3，通过WNT / Beta-catenin信号通路介导甲状腺癌进展

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Objective: Thyroid cancer is the most common endocrine tumor. A large number of thyroid cancer-related miRNAs have been studied and identified. However, the detailed roles of miR-574-5p in thyroid cancer remain poorly understood. This work mainly aimed to investigate the role of miR-574-5p/FOXN3 axis and its mechanism in the thyroid cancer progression.

机译：目的：甲状腺癌是最常见的内分泌肿瘤。已经研究并确定了大量甲状腺癌相关的miRNA。然而，miR-574-5p在甲状腺癌中的详细角色仍然明白。这项工作主要旨在探讨miR-574-5p / foxn3轴的作用及其在甲状腺癌进展中的机制。

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《Pathology Research and Practice》 |2020年第6期|共9页
作者
Zhang Zhe-Jia; Xiao Qian; Li Xin-Ying;
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作者单位

Cent South Univ Dept Gen Surg Xiangya Hosp 87 Xiangya Rd Changsha 410008 Peoples R China;

Cent South Univ Ctr Mental Hlth Serv Xiangya Hosp Changsha 410008 Hunan Peoples R China;

Cent South Univ Dept Gen Surg Xiangya Hosp 87 Xiangya Rd Changsha 410008 Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类病理学;
关键词
Thyroid cancer; MiRNA-574-5p; FOXN3; Wnt/beta-catenin pathway;

机译：甲状腺癌;mirona-574-5p;foxn3;wnt / beta-catenin途径;

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专利

1. MicroRNA-574-5p directly targets FOXN3 to mediate thyroid cancer progression via Wnt/beta-catenin signaling pathway [J] . Zhang Zhe-Jia, Xiao Qian, Li Xin-Ying Pathology Research and Practice . 2020,第6期

机译：MicroRNA-574-5P直接靶向FOXN3，通过WNT / Beta-catenin信号通路介导甲状腺癌进展
2. Drug development targeting the glycogen synthase kinase-3beta (GSK-3beta)-mediated signal transduction pathway: inhibitors of the Wnt/beta-catenin signaling pathway as novel anticancer drugs. [J] . Takahashi-Yanaga F, Sasaguri T Journal of pharmacological sciences. . 2009,第2期

机译：靶向糖原合酶激酶3β（GSK-3beta）介导的信号转导途径的药物开发：Wnt /β-catenin信号通路的抑制剂作为新型抗癌药物。
3. MicroRNA-552 promotes tumor cell proliferation and migration by directly targeting DACH1 via the Wnt/beta-catenin signaling pathway in colorectal cancer [J] . Cao Jia, Yan Xiu-Rui, Liu Ting, Oncology letters . 2017,第3aPta2期

机译：MicroRNA-552通过在结肠直肠癌中直接靶向DACH1来促进肿瘤细胞增殖和迁移
4. Involvement of Wnt pathway in thyroid cancer around Semipalatinsk Nuclear Test Site [C] . Serik K. Meirmanov, Masahiro Nakashima International Consortium for Medical Care of Hibakusha and Radiation Life Science . 2003

机译：WNT途径在塞古德癌核试验部位周围的甲状腺癌
5. Wnt/Beta-Catenin Signaling and the Tumor Microenvironment in Ewing Sarcoma Progression [D] . Hawkins, Allegra G. 2019

机译：Wnt / beta-catenin信号传导和肿瘤微环境在ewing sarcoma进展中
6. CONSORT: Sam68 Is Directly Regulated by MiR-204 and Promotes the Self-Renewal Potential of Breast Cancer Cells by Activating the Wnt/Beta-Catenin Signaling Pathway [O] . Lan Wang, Han Tian, Jie Yuan, -1

机译：结论：Sam68直接受MiR-204调控并通过激活Wnt /β-Catenin信号通路促进乳腺癌细胞的自我更新潜能。
7. Small Molecule Antagonists of the Wnt/Beta-Catenin Signaling Pathway Target Breast Tumor-Initiating Cells in a Her2/Neu Mouse Model of Breast Cancer [O] . Hallett, Robin M., Kondratyev, Maria K., Giacomelli, Andrew O., 2012

机译：Wnt / Beta-Catenin信号通路的小分子拮抗剂靶向乳腺癌Her2 / Neu小鼠模型中的乳腺癌肿瘤起始细胞。
8. Regulation of the Angiogenic Factor FGF Binding Protein (FGF-BP) by the APC/Beta-Catenin Signaling Pathway in the Progression of Breast Cancer [R] . Stylianou, D. C. 2004

机译：apC /β-Catenin信号通路在乳腺癌进展中对血管生成因子FGF结合蛋白（FGF-Bp）的调节

MicroRNA-574-5p directly targets FOXN3 to mediate thyroid cancer progression via Wnt/beta-catenin signaling pathway

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