A genetic association study between common variants in the ABCA13 gene and schizophrenia in a Han Chinese population

摘要

To the Editors: Recently, it has been reported that rare genetic variants in adenosine triphosphate (ATP)-binding cassetteA13 (ABCA13), located on human chromosome 7pl2.3, increase susceptibility to schizophrenia, bipolar disorder and major depression (Knight et al., 2009). However, some of the rare variants failed to replicate in a subsequent study utilizing an independent sample set (Dwyer et al., 2011), and two copy number variants (CNVs) in ABCA13 were not found to be significantly associated with schizophrenia and bipolar disorder (Pickard et al., 2012). Hence, we designed a case-control study to examine whether the common variants of ABCA13 gene were associated with schizophrenia in a Han Chinese sample.