Fluoxetine Hydrochloride 5 mg/0.1 mL in Pluronic Lecithin Organogel

摘要

Method of Preparation: Lecithin-isopropyl palmitate 1:1 solution—Prepare by mixing 0.2 g sorbic acid, 50 g of soy lecithin, and 50 g of isopropyl palmitate. Pluronic F127 20% solution—Prepare by mixing 0.2 g sorbic acid, 20 g of Pluronic F127, and sufficient purified water to make 100 mL. Fluoxetine HCl 5 mg/0.1 mL in Pluronic Lecithin Organogel—Calculate the quantity of each ingredient for the amount to be prepared. Accurately weigh or measure each ingredient. Pulverize the fluoxetine to a very fine powder. Add the alco hol and mix to form a smooth paste. Incorporate the lecithin: isopropyl palmitate solution to the paste and mix well. Geometrically, incorporate the Pluronic F127 20% gel to final volume and mix, using a mechanical shearing method, without incorporating air into the mixture. Package and label.