Role of heterotrimeric G proteins in platelet activation and clot formation in platelets treated with integrin alpha IIb beta 3 inhibitorr

摘要

Mechanisms of platelet activation are triggered by thrombin, adenosine diphosphate (ADP), epinephrine, thromboxane A(2), and other soluble agonists which induce signaling via heterotrimeric G alpha q, G alpha i, and G alpha 12/13 proteins. We have undertaken a study addressing the contribution of these G proteins to platelet activation and clot formation in the presence of eptifibatide, thus excluding outside-in signaling provided by integrin alpha IIb beta 3-fibrinogen engagement.