FUT8 drives the proliferation and invasion of trophoblastic cells via IGF-1/IGF-1R signaling pathway

摘要

Introduction: Trophoblast proliferation and invasion are essential for embryo implantation and placentation. Protein glycosylation is one of the most common and vital post-translational modifications, regulates protein physical and biochemical properties. FUT8 is the only known fucosyltransferase responsible for catalyzing alpha 1,6-fucosylation in mammals, and alpha 1,6-fucosylated glycoproteins are found to participate in various physiopathological processes. However, whether FUT8/alpha 1,6-fucosylation modulates the functions of trophoblastic cells remains elusive.