机译:将DPYD基因型翻译成DPD表型:使用DPYD基因活动分数
Netherlands Canc Inst Dept Med Oncol Div Clin Pharmacol Amsterdam Netherlands;
Leiden Univ Med Ctr Dept Med Oncol NL-2300 RC Leiden Netherlands;
Netherlands Canc Inst Dept Med Oncol Div Clin Pharmacol Amsterdam Netherlands;
Leiden Univ Med Ctr Dept Med Oncol NL-2300 RC Leiden Netherlands;
Netherlands Canc Inst Dept Gastroenterol &
Hepatol Amsterdam Netherlands;
Leiden Univ Med Ctr Dept Clin Pharm &
Toxicol NL-2300 RC Leiden Netherlands;
Netherlands Canc Inst Dept Med Oncol Div Clin Pharmacol Amsterdam Netherlands;
Leiden Univ Med Ctr Dept Clin Pharm &
Toxicol NL-2300 RC Leiden Netherlands;
capecitabine; dihydropyrimidine dehydrogenase; DPYD; 5-fluorouracil; fluoropyrimidines; gene activity score; individualized medicine; pharmacogenomics;
机译:将DPYD基因型转化为DPD表型:使用DPYD基因活性评分
机译:由于DPYD基因突变等位基因的杂合性,DPD活性低的患者5-FU清除率降低
机译:具有新的有害DPYD突变的家庭的基因分型支持以二氢尿嘧啶/尿嘧啶比率对DPD缺乏症进行治疗前筛查
机译:化学遗传程序设计-用于基因型-表型翻译的氨基酸重写规则的演变
机译:差分P53信号响应于5-fu和依托磷脂在癌症治疗中通过DPYD和CHK2调节毒性
机译:由于DPYD基因突变等位基因的杂合性DPD活性低的患者5-FU清除率降低
机译:由于DPYD基因突变等位基因的杂合性,DPD活性低的患者5-FU清除率降低