Additional data on citalopram and the risk of sudden cardiac death and ventricular arrhythmia

摘要

We appreciate the interest expressed by Dr. McKean et al.1 in our paper2 and take this opportunity to present additional data regarding citalopram from our study. The hazard ratio of sudden cardiac death/ventricular arrhythmia for 21–40?mg/day of citalopram versus ≤20?mg/day was 0.91 (95% confidence interval, 0.72–1.14) adjusting for age, sex, race, state of residence, nursing home residence status, number of prior prescriptions, and diagnosis of a substance abuse disorder. The hazard ratio for >40?mg/day versus ≤20?mg/day was 1.31 (95% confidence interval, 0.88–1.95) adjusting for these same variables. Thus, the results neither convincingly demonstrate a dose–response relationship nor necessarily rule one out.