Solid-State NMR Investigation of Drug-Excipient Interactions and Phase Behavior in Indomethacin-Eudragit E Amorphous Solid Dispersions

摘要

Purpose To investigate the nature of drug-excipient interactions between indomethacin (IMC) and methacrylate copolymer Eudragit (R) E (EE) in the amorphous state, and evaluate the effects on formulation and stability of these amorphous systems.