Development and Validation of a Method for Determining Lidocaine Hydrochloride and Miramistin in an Innovative Wound-Healing Gel

摘要

An HPLC-UV method for quantitative determination of lidocaine and miramistin in a combination wound-healing gel is reported. The method was validated for specificity, linearity, accuracy, and precision. The linear range for lidocaine hydrochloride was 0.08 - 0.12 mg/mL; for miramistin, 0.04 - 0.06 mg/mL. The linear correlation coefficients were 0.9992 and 0.9996 for lidocaine hydrochloride and miramistin, respectively. The method could be used for quantitative evaluation of lidocaine and miramistin in combination medicines.