Aggressive melanoma in an infant with congenital melanocytic nevus syndrome and multiple, NRAS NRAS NRAS and BRAF BRAF BRAF mutation‐negative nodules

摘要

Abstract We report the case of a newborn boy with multinodular NRAS and BRAF mutation‐negative congenital melanocytic nevi and cerebral lesions compatible with congenital intraparenchymal melanosis. Histopathology from skin lesions showed atypical nodular melanocytic proliferation with marked melanocytic atypia and a large number of mitoses and apoptosis, indicating aggressive proliferation. The child developed several new subcutaneous tumors and multiple internal lesions, which were confirmed to be metastases, and died at 5?months of age. This case may represent an infantile melanoma developing from a giant congenital melanocytic nevus or a congenital melanoma.