Re-treatment with high-dose prednisolone after rituximab infusion for childhood-onset steroid-resistant nephrotic syndrome

摘要

We read with great interest the article titled "Rituximab treatment combined with methylprednisolone pulse therapy and immunosuppressants for childhood steroid-resistant nephrotic syndrome" by Kamei et al., which has recently appeared in Pediatric Nephrology [1]. In this retrospective observational study often children with refractory steroid-resistant nephrotic syndrome (SRNS), seven patients (70 %) achieved complete remission after receiving multiple courses of methylprednisolone pulse therapy (MPT) and immunosuppressive agents administered after one to four doses of rituximab (RTX).