Evaluation of phenytoin serum levels following a loading dose in the acute hospital setting

摘要

Highlights ? PHT serum levels of either ? Despite proper dosing, PHT serum level could be low in the first hours of treatment. ? The correlation between free and total serum PHT levels was weak. Abstract Purpose Due to the complex pharmacokinetic profiles of phenytoin (PHT) and fosphenytoin (FOS), achieving sustained, targeted serum PHT levels in the first day of use is challenging. Methods A population based approach was used to analyze total serum PHT (tPHT) level within 2–24h of PHT/FOS loading with or without supplementary maintenance or additional loading doses among PHT-na?ve patients in the acute hospital setting. Adequate tPHT serum level was defined as ≥20μg/mL. Results Among 494 patients with 545 tPHT serum levels obtained in the first 2–24h after the loading dose (LD), tPHT serum levels of either Conclusion Close laboratory surveillance and PHT/FOS dose adjustments are recommended to ensure adequate and sustained tPHT serum levels early in treatment. Free serum PHT level is the preferred method of drug monitoring.