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首页> 外文期刊>Molecular Neurobiology >Association of DISC1 Polymorphisms with Late-Onset Alzheimer's Disease in Northern Han Chinese
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Association of DISC1 Polymorphisms with Late-Onset Alzheimer's Disease in Northern Han Chinese

机译:Disc1多态性与晚期汉族北部患有晚期的Alzheimer疾病的关系

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摘要

The disrupted-in-schizophrenia-1 (DISC1) is a candidate gene for psychiatric diseases and plays various roles in brain development. It has been reported as a candidate gene for Alzheimer's disease (AD) in a recent large genome-wide association study in Caucasians. To explore the associations between DISC1 and AD, we performed a case-control study including 2318 subjects in Northern Han Chinese. We found that one single nucleotide polymorphism (rs6675281) was associated with the risk of late-onset Alzheimer's disease (LOAD) in northern Han Chinese population. As for rs821616 and rs3738401, no association was detected with LOAD. In conclusion, DISC1 increased the risk for LOAD in northern Han Chinese population.
机译:中断的精神分裂症-1(Disc1)是精神疾病的候选基因,并在脑发育中发挥各种作用。 据报道,近期高加索人近期大型基因组关联研究中的阿尔茨海默病(AD)候选基因。 为了探索Disc1和AD之间的协会,我们进行了案例对照研究,包括汉族北部汉族的2318名科目。 我们发现,一种单一核苷酸多态性(RS6675281)与汉族北部北部患有晚期阿尔茨海默病(负荷)的风险有关。 至于RS821616和RS3738401,没有载荷检测关联。 总之,DISC1增加了汉族人口负荷的风险。

著录项

  • 来源
    《Molecular Neurobiology》 |2017年第4期|共6页
  • 作者单位

    Qingdao Univ Sch Med Qingdao Municipal Hosp Dept Neurol 5 Donghai Middle Rd Qingdao 266071;

    Nanjing Med Univ Qingdao Municipal Hosp Dept Neurol Qingdao Peoples R China;

    Qingdao Univ Sch Med Qingdao Municipal Hosp Dept Neurol 5 Donghai Middle Rd Qingdao 266071;

    Qingdao Univ Sch Med Qingdao Municipal Hosp Dept Neurol 5 Donghai Middle Rd Qingdao 266071;

    Qingdao Mental Hlth Ctr Dept Geriatr Qingdao 266034 Peoples R China;

    Qingdao Mental Hlth Ctr Dept Geriatr Qingdao 266034 Peoples R China;

    Qingdao Univ Sch Med Qingdao Municipal Hosp Dept Neurol 5 Donghai Middle Rd Qingdao 266071;

    Qingdao Univ Sch Med Qingdao Municipal Hosp Dept Emergency Qingdao Peoples R China;

    Qingdao Univ Sch Med Qingdao Municipal Hosp Dept Neurol 5 Donghai Middle Rd Qingdao 266071;

    Ocean Univ China Coll Med &

    Pharmaceut Qingdao 266000 Peoples R China;

    Nanjing Med Univ Nanjing Hosp 1 Dept Neurol Nanjing Jiangsu Peoples R China;

    Qingdao Univ Sch Med Qingdao Municipal Hosp Dept Neurol 5 Donghai Middle Rd Qingdao 266071;

    Qingdao Univ Sch Med Qingdao Municipal Hosp Dept Neurol 5 Donghai Middle Rd Qingdao 266071;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 人体生理学;
  • 关键词

    DISC1; Alzheimer's disease; Polymorphism; Association;

    机译:Disc1;阿尔茨海默病;多态性;联想;

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