CATALYST-CONTROLLED GLYCOSYLATION

摘要

The selective laboratory synthesis of carbohydrates is one of the longest-standing challenges in the field of organic chemistry. Because of the enormous structural diversity of glycosylated compounds and their crucial importance in virtually all biological processes, identification of general approaches to the stereo- and site-selective coupling of sugars remains a major goal.1'2 Chemical glycosylation methods have been reviewed extensively,1-16 encompassing many useful methods for constructing glycosidic linkages, both natural and unnatural. Classical methods and approaches to glycosylation typically rely on specific reagents and protecting groups on both coupling partners to influence the stereo- and site selectivity of the reaction.