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Mechanistic Study on Triptorelin Action in Protecting From 5-FU-Induced Ovarian Damage in Rats

机译:曲素素作用对大鼠5夫诱发卵巢损伤保护的曲素素作用

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Triptorelin, a kind of GnRH agonist, is widely used in the treatment of hormone-responsive cancers in the clinic. This study aimed to discover the underlying mechanism of triptorelin in protection from 5-fluorouracil (5-FU)-induced ovarian damage in Sprague-Dawley rats. In the present study, after using 5-FU to induce ovarian damage in rats, body weight and wet ovaries were weighed, the levels of estradiol (E2), follicle-stimulating hormone (FSH), and anti-Miillerian hormone (AMH) in blood were detected, and the expression of Bcl-2, Bax, and NF-kB was determined. It suggested that, compared to the control, body weight gain, the ratio of ovarian wet weight to body weight, primary follicle numbers, and the levels of AMH were significantly decreased, while the concentration of E2 and FSH was heavily increased following 5-FU administration. In contrast, after coadministration of triptorelin with 5-FU, the ratio of ovarian wet weight to body weight and the levels of AMH were significantly increased, whereas the level of E2 and FSH was decreased significantly when compared with the 5-FU group. Furthermore, at indicated times, 5-FU led to the reduced Bcl-2 and NF-kB expression and increased Bax expression while triptorelin plus 5-FU increased Bcl-2 and NF-kB expression and decreased Bax expression. It was indicated that triptorelin could protect rats from 5-FU-induced ovarian damage by modulation of hormones, Bcl-2, Bax, and NF-kB. These results might highlight the mechanism of triptorelin as a protective agent in clinical chemotherapy for ovarian damage.
机译:Triptorin,一种GNRH激动剂,广泛用于诊所治疗激素响应癌症。该研究旨在发现曲素素保护免受5-氟尿嘧啶(5-FU) - 屈服卵巢损伤在Sprague-Dawley大鼠中的潜在机制。在本研究中,在使用5-fu在大鼠诱导卵巢损伤后,体重和湿卵巢称重,雌二醇(E2)的水平,卵泡刺激激素(FSH),以及抗Miillerian激素(AMH)检测血液,测定Bcl-2,Bax和NF-Kb的表达。它表明,与对照,体重增加,卵巢湿重与体重,初级卵泡数的比率相比,AMH水平显着降低,而E2和FSH的浓度在5-FU后大幅增加行政。相反,在用5-FU的曲素素的共同分配后,卵巢湿重与体重和AMH水平的比例显着增加,而与5-FU组相比,E2和FSH的水平显着降低。此外,在指定的时间,5-FU导致降低的Bcl-2和NF-Kb表达,并增加了Bax表达,而Triptorin加5-Fu增加了Bcl-2和NF-Kb表达和减少的Bax表达。结果表明,Triptorin可以通过调制激素,Bcl-2,Bax和NF-Kb来保护来自5-Fu诱发的卵巢损伤的大鼠。这些结果可能突出Triptorin作为卵巢损伤临床化学治疗中的保护剂的机制。

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