Cherchez la femme: Maternal Incidental Findings Can Explain Discordant Prenatal Cell-free DNA Sequencing Results EDITORIAL COMMENT

摘要

(Abstracted from Genet Med 2018;20:910-917) Maternal plasma DNA sequencing has been offered as an alternative to biochemical and sonographic screening tests for fetal aneuploidy since 2011. The circulating cell-free DNA (cfDNA) fragments in the peripheral blood sample of a pregnant woman derive from 3 tissues: placenta, maternal bone marrow, and the fetus (or fetuses).