Synthesis of Some New Thiazole Derivatives and Their Cytotoxicity on Different Human Tumor Cell Lines

摘要

Some novel 1-(inden-3-ylidene)-2-(thiazol-2-ylidene) hydrazine derivatives 3-9 were synthesized by the Hantzsch reaction of thiosemicarbazone derivatives 2a-2c with halo ketones and halo esters. Thiosemicarbazone derivatives reacted with hydrozonyl chlorides to give diazenyl-4-methylthiazole derivatives 11a-11d. Structures of the products were elucidated from IR, H-1, and C-13 NMR, and Mass spectra elucidate. The synthesized compounds were screened for their cytotoxicity against three human tumor cell lines. Twenty compounds showed high (= 60 %) antiproliferative activity over breast cancer (MCF-7). Compounds 2b, 3c, 4a, 4b, 6b, 6c, 7b, 8a, and 11b possessed higher cytotoxic activity over breast tumor cell line than Doxorubicin.