3,3-Bis(2-nitroxyethyl) derivatives of 1,1 '-[methylenebis(oxy)]bis(triaz-1-ene 2-oxides) as a new type of NO donors

摘要

3,3-Bis(2-nitroxyethyl) derivatives of 1,1 '-[methylenebis(oxy)]bis(triaz-1-ene 2-oxides) were synthesized by either nucleophilic substitution of the bromine atoms of parent 3,3-bis(2- bromoethyl) compounds or nitration of structurally related 3,3-bis(2-hydroxyethyl) derivatives. The synthesized compounds comprise two different NO donating moieties, namely, oxytriaz- 1-ene 2-oxide and nitrate groups, and, therefore, can be regarded as a new type of NO-donating agents.