Synthesis of sodium 5-sulfate-ivermectin and disodium 4″,5-disulfate-ivermectin

M. A. Shchetinina; E. I. Chernoburova; N. G. Kolotyrkina; M. Kh. Dzhafarov; F. I. Vasilevich; I. V. Zavarzin

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Synthesis of sodium 5-sulfate-ivermectin and disodium 4″,5-disulfate-ivermectin

机译：合成5-硫酸钠-Ivermectin和14“，5-二硫酸盐-Ivermectin

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摘要

Treatment of ivermectin with sulfuric acid–acetic anhydride in pyridine gives sodium 5-sulfate-ivermectin and disodium 4″,5-disulfate-ivermectin. The synthesized salts are water-soluble compounds with promising antiparasitic activity.

机译：吡啶中硫酸乙酸酐用硫酸氨苄酸钠治疗吡啶钠，得到5-硫酸钠 - 伊维霉菌素，二硫酸钠 - 伊硫酸盐。合成的盐是具有有前途的抗遗传性活性的水溶性化合物。

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来源
《Russian Chemical Bulletin》 |2018年第5期|共4页
作者
M. A. Shchetinina; E. I. Chernoburova; N. G. Kolotyrkina; M. Kh. Dzhafarov; F. I. Vasilevich; I. V. Zavarzin;
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作者单位

N. D. Zelinsky Institute of Organic Chemistry Russian Academy of Sciences;

N. D. Zelinsky Institute of Organic Chemistry Russian Academy of Sciences;

N. D. Zelinsky Institute of Organic Chemistry Russian Academy of Sciences;

K. I. Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology;

K. I. Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology;

N. D. Zelinsky Institute of Organic Chemistry Russian Academy of Sciences;

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原文格式 PDF
正文语种 eng
中图分类化学;
关键词
sulfation; ivermectin; sulfuric acid; acetic anhydride; sodium salt of ivermectin 5-sulfate; disodium salt of ivermectin 4″; 5-disulfate;

机译：硫酸盐;伊维菌素;硫酸;乙酸酐;伊维菌素钠盐5-硫酸盐;伊维菌素的二钠盐4“;5-二硫酸盐;

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1. Synthesis of sodium 5-sulfate-ivermectin and disodium 4aEuro(3),5-disulfate-ivermectin [J] . Shchetinina M. A., Chernoburova E. I., Kolotyrkina N. G., Fortschritte der Physik . 2018,第5期

机译：合成5-硫酸钠-Ivermectin和4.Aeuro（3），5-二硫甲醛 - 伊维霉菌素
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Synthesis of sodium 5-sulfate-ivermectin and disodium 4″,5-disulfate-ivermectin

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