Synthesis of sodium 5-sulfate-ivermectin and disodium 4aEuro(3),5-disulfate-ivermectin

Shchetinina M. A.; Chernoburova E. I.; Kolotyrkina N. G.; Dzhafarov M. Kh.; Vasilevich F. I.; Zavarzin I. V.

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Synthesis of sodium 5-sulfate-ivermectin and disodium 4aEuro(3),5-disulfate-ivermectin

机译：合成5-硫酸钠-Ivermectin和4.Aeuro（3），5-二硫甲醛 - 伊维霉菌素

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摘要

Treatment of ivermectin with sulfuric acid-acetic anhydride in pyridine gives sodium 5-sulfate-ivermectin and disodium 4aEuro(3),5-disulfate-ivermectin. The synthesized salts are water-soluble compounds with promising antiparasitic activity.

机译：吡啶中硫酸乙酸酐用硫酸氨苄酸钠治疗吡啶钠，得到5-硫酸钠 - 伊维菌素和含有5-二硫酸盐 - 伊维霉素。合成的盐是具有有前途的抗遗传性活性的水溶性化合物。

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《Fortschritte der Physik》 |2018年第5期|共4页
作者
Shchetinina M. A.; Chernoburova E. I.; Kolotyrkina N. G.; Dzhafarov M. Kh.; Vasilevich F. I.; Zavarzin I. V.;
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作者单位

Russian Acad Sci ND Zelinsky Inst Organ Chem 47 Leninsky Prosp Moscow 119991 Russia;

Russian Acad Sci ND Zelinsky Inst Organ Chem 47 Leninsky Prosp Moscow 119991 Russia;

Russian Acad Sci ND Zelinsky Inst Organ Chem 47 Leninsky Prosp Moscow 119991 Russia;

KI Skryabin Moscow State Acad Vet Med &

Biotech 23 Ul Akad Skryabina Moscow 109472 Russia;

KI Skryabin Moscow State Acad Vet Med &

Biotech 23 Ul Akad Skryabina Moscow 109472 Russia;

Russian Acad Sci ND Zelinsky Inst Organ Chem 47 Leninsky Prosp Moscow 119991 Russia;

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原文格式 PDF
正文语种 eng
中图分类物理学;
关键词
sulfation; ivermectin; sulfuric acid; acetic anhydride; sodium salt of ivermectin 5-sulfate; disodium salt of ivermectin 4 ''; 5-disulfate;

机译：硫化;伊维菌素;硫酸;乙酸酐;伊维霉素钠盐5-硫酸盐;伊维菌素4''的二钠盐;5-二硫酸盐;

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1. Synthesis of sodium 5-sulfate-ivermectin and disodium 4aEuro(3),5-disulfate-ivermectin [J] . Shchetinina M. A., Chernoburova E. I., Kolotyrkina N. G., Fortschritte der Physik . 2018,第5期

机译：合成5-硫酸钠-Ivermectin和4.Aeuro（3），5-二硫甲醛 - 伊维霉菌素
2. Recrystallization synthesis of disodium rhodizonate-conductive polyaniline composite with high cyclic performance as cathode material of sodium-ion battery [J] . Applied Surface Science . 2020,第Jana1期

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3. Synthesis and performances of biodegradable copolymers of disodium cis-epoxysuccinate and 2,3-oxiranernethane sulfonic acid sodium used as nonphosphoric detergent builders [J] . Zhu Dongyu, Guo Jianwei, Chen Shaohua, Polymer bulletin . 2015,第1期

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4. The Synthesis of C-14 and Tritium Labeled N-4-2-(2-Amino-4,7-dihduydro-4-1H-pyrrolo2,3-dpyrimidin-5-yl)ethyol -L-gluatamic Acid, Disodium Salt(LY231514 diNa, ALIMTA?, Pemetrexed Disodium) [C] . Douglas D. OBannon, William J. Wheeler, Barry C. Peterson International Symposium on the Synthesis and Applications of Isotopes and Isotopically Labelled Compounds . 2004

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5. Desorption Ionization by Charge Exchange (DICE) and collision-induced dissociation of sodium adducts of disodium salts of benzene dicarboxylic acids [D] . Chan, ChangChing 2010

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6. The relative toxicity in rats of disodium ethylene diamine tetra-acetate sodium oxalate and sodium citrate [O] . J. M. Payne, B. F. Sansom 1964

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Synthesis of sodium 5-sulfate-ivermectin and disodium 4aEuro(3),5-disulfate-ivermectin

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