Reply to: Comment on 'Usefulness of cerebral rSO2 monitoring during CPR to predict the probability of return of spontaneous circulation'

摘要

Dear Editor, We greatly appreciate the comments by Yarong He et al. implying that the significance of correlation between DrSO2 and ROSC might depend on the causes of CA, therefore stratification analysis by cause of CA may verify the prognostic effects of DrSO2 for ROSC. In the study cohort, reasons for CA were summarized as follows: 7 patients with aortic dissection, 6 patients with drowning, and 5 patients with asphyxiation (Table 1). Because of many strata of CA reasons, it is difficult to convey a meaningful analysis within each stratum of CA reason. In addition, in our paper, we rather focus on the adding predictive ability of the amount of change in the maximum value from the baseline value at 16min; and that the combination of baseline rSO2 value with the amount of maximum rise from the baseline rSO2 value during cardiopulmonary resuscitation might be a new prognostic index for the prediction of the return of spontaneous circulation (ROSC) in out-of-hospital cardiac arrest. The regression analysis we employed has brought enough complexity by including the interaction term which corresponds to the combination of two risk factors, and stratification analysis may harm stability of the analytical results due to overfitting.