Antimicrobial activity of new dumbbell-shaped phenothiazine cinnamides

摘要

Herein, we report the synthesis and in vitro antibacterial and antifungal activities for twelve (E)-3-(10-(4-(10H-phenothiazin-10-yl)phenyl)-10H-phenothiazin-3-yl)-N-phenyl acrylamides (1-12). Structures of the compounds were established using IR, H-1 NMR, mass and elemental analysis. These compounds exhibited promising activity against bacterials rather than fungal strains used. All the compounds inhibited the Gram-negative E. coli (ATCC 25922) and compounds 3, 5, 7, 8 and 12 also inhibited Gram-negative Pseudomonas (ATCC 27853) species in nano molar concentrations. Disc diffusion and micro-dilution (for MIC) methods were employed in estimating their in vitro antibacterial and antifungal activities. Ciprofloxacin and ketoconazole were used as the respective internal standards.