Synthesis and evaluation of antimicrobial and anthelmintic activity of novel fluorinated 7-ethyl-10e???-phenothiazines, their sulphones and ribofuranosides

摘要

A series of novel fluorinated 10e???-phenothiazines were synthesized via Smiles rearrangement. 10e???-phenothiazines on refluxing with 30% hydrogen peroxide in glacial acetic acid gave 10e???-phenothiazines-5, 5-dioxides (sulphones). These synthesized 10e???-phenothiazines were then used as base to prepare ribofuranosides by treating them with sugar (e???-D-ribofuranosyl- 1-acetate-2, 3, 5-tribenzoate). The synthesized compounds were screened for antimicrobial activity and anthelmintic activity. The structural assignments of compounds were made on the basis of spectroscopic data and elemental analysis.