Ion Sensitive Floating In Situ gel for Controlled Delivery of Famotidine and Domperidone Maleate for the Treatment of Gastro Oesophageal Reflux Disease

摘要

The purpose of present investigation was to develop stomach specific floating controlled release in-situ gelling system of Famotidine and Domperidone maleate to treat gastro oesophageal reflux disease. The stomach specific in-situ gel was prepared by ionic gelation method using different polymers of varied concentrations of sodium alginate and hydroxy propyl methyl cellulose K4M. The prepared in-situ gel was characterized for their physical appearance, viscosity, pH, floating behaviour, gelling time, gelling capacity, drug content, and drug release and stability studies. The result of all the parameters indicated that F8 formulation was found better because formulation Fs showed instantaneous gelation when came in contact with 0.1N hydrochloric acid and remain as gel form for few hours. It showed optimum viscosity so were pourable at normal condition. Floating behavior showed highest floating time and the in-vitro release of Famotidine and Domperidone maleate of in-situ gel formulation was found to be 97.45±0.20 and 95.18±0.29 respectively at the end of 12 hours and this formulation was considered as best formulation. All the formulations were subjected to different kinetic investigation such as zero order model, first order model, Higuchi model, Korsmeyer-Peppas model and the result indicated that almost all formulations followed zero order release kinetics with super case II transport mechanism. Stability study was conducted for successful formulation according to ICH guidelines. The results have shown that there was less variation in the physical appearance, drug content and drug release profile.