In Vitro Antioxidant effect of Green Tea Polyphenol Epigallocatechin-3-Gallate (EGCG) in Protecting Cardiovascular Diseases

摘要

The aim of this study focused on the beneficial effect of EGCG which possess direct antioxidant potential in scavenging the free radicals. Therefore, EGCG was considered as one of the natural antioxidant in improving the quality of life by preventing cardiovascular diseases. Free radicals play an important role in triggering cardiovascular diseases (CVD) like atherosclerosis, diabetic cardiomyopathy, heart failure etc., with large number of risk factors like hypercholesterolemia, hypertension, diabetes, stress (Bahorunet al;Ceriello A). Oxidative stress was considered as a primary or a secondary cause for diabetic cardiomyopathy (Droge W).Therefore, modulation of oxidative stress signifies an important approach for the treatment of diabetic cardiomyopathy. EGCG in green tea act as a dietary antioxidant by scavenging reactive oxygen species (ROS) and also have the ability to chelate metal ions such as iron which contribute to antioxidant activity (Rice-Evans et al; Brownet al).