Detection of the iron complexes with hydrolysis products of cephalexin and cefradine upon high-performance liquid chromatography/electrospray ionization mass spectrometry analysis

摘要

RationaleCephalosporins (e.g. cephalexin, cefradine) are a major group of widely used -lactam antibiotics. Hydrolysis of the -lactam ring is an important reaction (often undesired) which leads to deactivation of -lactams. To the best of our knowledge there is no electrospray ionization mass spectrometry (ESI-MS) data reported concerning the products of hydrolysis of cephalosporins.