Canadian Cancer Trials Group (CCTG) IND211: A randomized trial of pelareorep (Reolysin) in patients with previously treated advanced or metastatic non-small cell lung cancer receiving standard salvage therapy

Bradbury Penelope A.; Morris Donald G.; Nicholas Garth; Tu Dongsheng; Tehfe Moustapha; Goffin John R.; Shepherd Frances A.; Gregg Richard W.; Rothenstein Jeffrey; Lee Christoper; Kuruvilla Sara; Keith Bruce D.; Torri Vamsee; Blais Normand; Hao Desiree; Korpanty Grzegorz J.; Goss Glenwood; Melosky Barbara L.; Mates Mihaela; Leighl Natasha; Ayoub Jean-Pierre; Sederias Joana; Feilotter Harriet; Seymour Lesley; Laurie Scott A.

首页> 外文期刊>Lung cancer: Journal of the International Association for the Study of Lung Cancer >Canadian Cancer Trials Group (CCTG) IND211: A randomized trial of pelareorep (Reolysin) in patients with previously treated advanced or metastatic non-small cell lung cancer receiving standard salvage therapy

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Canadian Cancer Trials Group (CCTG) IND211: A randomized trial of pelareorep (Reolysin) in patients with previously treated advanced or metastatic non-small cell lung cancer receiving standard salvage therapy

机译：加拿大癌症试验组（CCTG）IND211：在接受标准救助治疗的先前治疗的晚期或转移性非小细胞肺癌患者中Pelareorep（Reolysin）的随机试验

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Objectives: Pelareorep (reolysin), a Dearing strain of reovirus serotype 3, has demonstrated oncolytic activity as single agent and synergy with chemotherapy. We evaluated pelareorep, combined with standard second-line chemotherapy in patients with non-small cell lung cancer (NSCLC).

机译：目的：Pelareorep（Reolysin）是一种贪婪的reovirus血清型3株，已作为单一剂和化疗协同作用。我们评估了Pelareorep，结合了非小细胞肺癌（NSCLC）患者的标准二线化疗。

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来源
《Lung cancer: Journal of the International Association for the Study of Lung Cancer》 |2018年第2018期|共7页
作者
Bradbury Penelope A.; Morris Donald G.; Nicholas Garth; Tu Dongsheng; Tehfe Moustapha; Goffin John R.; Shepherd Frances A.; Gregg Richard W.; Rothenstein Jeffrey; Lee Christoper; Kuruvilla Sara; Keith Bruce D.; Torri Vamsee; Blais Normand; Hao Desiree; Korpanty Grzegorz J.; Goss Glenwood; Melosky Barbara L.; Mates Mihaela; Leighl Natasha; Ayoub Jean-Pierre; Sederias Joana; Feilotter Harriet; Seymour Lesley; Laurie Scott A.;
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作者单位

Univ Toronto Princess Margaret Canc Ctr 610 Univ Ave Toronto ON M5G 2M9 Canada;

Tom Baker Canc Clin 1331 29 St NW Calgary AB T2N 4N2 Canada;

Ottawa Hosp Res Inst 501 Smyth Rd Ottawa ON K1H 8L6 Canada;

Queens Univ Canadian Canc Trials Grp 10 Stuart St Kingston ON K7L 3N6 Canada;

CHUM Hop Notre Dame 1560 Rue Sherbrooke Est Montreal PQ H2L 4M1 Canada;

Hamilton Hlth Sci Juravinski Canc Ctr 699 Concession St Hamilton ON L8V 5C2 Canada;

Univ Toronto Princess Margaret Canc Ctr 610 Univ Ave Toronto ON M5G 2M9 Canada;

Canc Ctr Southeastern Ontario 25 King St West Kingston ON K7L 5P9 Canada;

Lakeridge Hlth Oshawa 1 Hosp Court Oshawa ON L1G 2B9 Canada;

BCCA Fraser Valley Canc Ctr 13750 96th Ave Surrey BC V3V 1Z2 Canada;

London Reg Canc Program 790 Commissioners Rd East London ON N6A 4L6 Canada;

BCCA Abbotsford Ctr 32900 Marshall Rd Abbotsford BC V2S 0C2 Canada;

Allan Blair Canc Ctr Regina SK Canada;

CHUM Hop Notre Dame 1560 Rue Sherbrooke Est Montreal PQ H2L 4M1 Canada;

Tom Baker Canc Clin 1331 29 St NW Calgary AB T2N 4N2 Canada;

Queens Univ Canadian Canc Trials Grp 10 Stuart St Kingston ON K7L 3N6 Canada;

Ottawa Hosp Res Inst 501 Smyth Rd Ottawa ON K1H 8L6 Canada;

BCCA Vancouver Canc Ctr 600 West 10th Ave Vancouver BC V5Z 4E6 Canada;

Canc Ctr Southeastern Ontario 25 King St West Kingston ON K7L 5P9 Canada;

Univ Toronto Princess Margaret Canc Ctr 610 Univ Ave Toronto ON M5G 2M9 Canada;

CHUM Hop Notre Dame 1560 Rue Sherbrooke Est Montreal PQ H2L 4M1 Canada;

Queens Univ Canadian Canc Trials Grp 10 Stuart St Kingston ON K7L 3N6 Canada;

Queens Univ 99 Univ Ave Kingston ON K7L 3N6 Canada;

Queens Univ Canadian Canc Trials Grp 10 Stuart St Kingston ON K7L 3N6 Canada;

Ottawa Hosp Res Inst 501 Smyth Rd Ottawa ON K1H 8L6 Canada;

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原文格式 PDF
正文语种 eng
中图分类肿瘤学;
关键词
Clinical trial; Randomized; Non-small cell lung cancer; Pelareorep;

机译：临床试验;随机;非小细胞肺癌;Pelareorep;

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专利

1. Canadian Cancer Trials Group (CCTG) IND211: A randomized trial of pelareorep (Reolysin) in patients with previously treated advanced or metastatic non-small cell lung cancer receiving standard salvage therapy [J] . Bradbury Penelope A., Morris Donald G., Nicholas Garth, Lung cancer: Journal of the International Association for the Study of Lung Cancer . 2018,第期

机译：加拿大癌症试验组（CCTG）IND211：在接受标准救助治疗的先前治疗的晚期或转移性非小细胞肺癌患者中Pelareorep（Reolysin）的随机试验
2. Canadian Cancer Trials Group (CCTG) IND215: A phase Ib study of Selumetinib in patients with untreated advanced or metastatic NSCLC who are receiving standard chemotherapy regimens [J] . J. R. Goffin, G. Nicholas, M. Mates, Investigational new drugs. . 2019,第3期

机译：加拿大癌症试验组（CCTG）IND215：一种接受标准化疗方案的未经治疗的晚期或转移NSCLC患者Selumetinib的IB研究
3. Randomized phase III trial of docetaxel versus vinorelbine or ifosfamide in patients with advanced non-small-cell lung cancer previously treated with platinum-containing chemotherapy regimens. The TAX 320 Non-Small Cell Lung Cancer Study Group. [J] . Fossella FV, DeVore R, Kerr RN, Journal of Clinical Oncology . 2000,第12期

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4. IMPROVING PREDICTION OF SURVIVAL USING CT-BASED TUMOR CHARACTERISTICS IN PATIENTS TREATED FOR METASTATIC NON-SMALL CELL LUNG CANCER [C] . WALKER H. LAND JR., ALAN LITWIN, DAN MARGOLIS, Artificial Neural Networks in Engineering Conference . 2010

机译：基于CT基肿瘤特征改善对转移性非小细胞肺癌的患者的肿瘤特征预测
5. Predictive Biomarkers of the Efficacy of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Treating Advanced Non-small Cell Lung Cancer: A Systematic Review of Randomized Controlled Trials [D] . Yang, Zuyao. 2014

机译：表皮生长因子受体酪氨酸激酶抑制剂治疗晚期非小细胞肺癌疗效的预测生物标志物：随机对照试验的系统评价。
6. Quality of life in advanced non-small cell lung cancer patients receiving palliative chemotherapy: A meta-analysis of randomized controlled trials [O] . AYAKO MATSUDA, KAZUE YAMAOKA, TOSHIRO TANGO -1

机译：接受姑息性化疗的晚期非小细胞肺癌患者的生活质量：一项随机对照试验的荟萃分析
7. Simple nutritional intervention in patients with advanced cancers of the gastrointestinal tract, non-small cell lung cancers or mesothelioma and weight loss receiving chemotherapy: a randomised controlled trial [O] . Baldwin, C., Spiro, A., McGough, C., 2011

机译：接受化疗的晚期胃肠道癌，非小细胞肺癌或间皮瘤患者的简单营养干预：一项随机对照试验

Canadian Cancer Trials Group (CCTG) IND211: A randomized trial of pelareorep (Reolysin) in patients with previously treated advanced or metastatic non-small cell lung cancer receiving standard salvage therapy

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