Nonlinear Analysis of Quantitative EEGs in Patients with Syndromes of Post-Coma Disorders of Consciousness after Severe Traumatic Brain Injury

摘要

Electroencephalograms of 220 patients with post-coma disorders of consciousness after severe traumatic brain injury were analyzed using nonlinear multidimensional analysis, and the results were compared with those of standard linear time-amplitude analysis. Quantitative multichannel EEGs were recorded in the course of one-year-long clinical restorative treatment and rehabilitation. We tried to identify informative indices obtained using nonlinear analysis, which most closely correlated with the dynamics of the syndromes of altered consciousness (classification according to Dobrokhotova [34]). The diagnostic informational value of the results of nonlinear analysis of quantitative EEGs and sensitivity of this methodical approach in predicting positive/negative dynamics of consciousness recovery were estimated. Results of mapping of the values of entropy, dimension of the brain dynamic systems (complexity), parameters of the attractors, and multifractal properties of EEGs in different patient groups are described. It is concluded that the obtained results of nonlinear analysis demonstrate sertain advantages in prediction of the clinical course of post-coma disturbances of consciousness after brain trauma.