Neuropeptides: A promising target for treating seizures

摘要

Abstract Seizures are serious neurological disorders affecting nearly 50 million people worldwide. Seizures are characterized by abnormal, repetitive and synchronised firing of the neurons which is produced as a result of imbalance in the levels of the excitatory and inhibitory neurotransmitters. Neuropeptides are found to regulate seizures by rectifying this imbalance. These neuropeptides are stored in the dense core synaptic vesicles, and are released on excitation. This review focuses on certain neuropeptides which can alleviate both, the effects of seizures as well as epileptogenesis. Thus making it an attractive target for the management of seizures. Highlights ? Certain neuropeptides can deteriorate the effects of seizures as well as epileptogenesis. ? Modulations of these neuropeptides can be used for the management of seizures. ? These neuropeptides can be targeted in treatment of epileptogenesis as well as severe effects of seizures. ]]>