2,4-Disubstituted 4-(1,3-thiazol-5-yl)but-3-en-2-ones: synthetic approaches to and consequent chemical modification

摘要

Arylideneketones are commonly considered as convenient starting materials for obtaining compounds of potential pharmaceutical interest. Heterocyclic alpha,beta-unsaturated representatives of this series possess chemical and biological properties worth study in details. Particularly, substituted thiazole cycle, incorporated into such a system, allows obtaining of new biologically active products suitable to their consequent chemical modification. In this communication we focus attention on 2,4-disubstituted 4-(1,3-thiazol-5-yl)but-3-en-2-ones on the background of 2,4-dihalogen-5-formylthiazole, several relevant methods of their synthesis and prospective directions of further chemical modification.