Rapid and efficient protocol for Willgerodt-Kindler's thioacetamides catalyzed by sulfated polyborate

摘要

A simple and efficient method for the synthesis of one-pot, three-component thioacetamides via Willgerodt-Kindler reaction was developed using a sulfated polyborate catalyst. The method described the reaction of ketones, sulfur, and secondary amines with high yields under a solvent-free condition at 100 A degrees C. The key advantages of the present method are short reaction time, high yields, solvent-free condition, and recyclability of a catalyst which gives economical as well as ecological rewards.