Synthesis and antimicrobial evaluation of some ethoxyphthalimide derivatives of 3-(substituted phenyl)-4-methyl-3a, 6-dihydropyrazolo[3,4-c] pyrazol-2(3H)-yl(pyridin-3-yl)methanone

摘要

5-Methyl-2,4-dihydro-3H-pyrazol-3-one (1) reacted with substituted benzaldehydes (2a-d) in the presence of anhydrous sodium acetate to gave corresponding 4-arylidene-5-methyl-2,4-dihyro-3H-pyrazol-3-ones (3a-d). Further condensation of (3a-d) with 2-bromoethoxy-1H-isoindole-1,3-(2H)-dione (II) in the presence of pyridine as a base furnished 2-[2-(4-arylidene-3-methyl-5-oxo-4,5-dihydro-pyrazol-1 -yl)ethoxy]-isoindole-1,3-diones (4a-d), which on cyclisation with nicotinohydrazide (I) afforded titled compounds 6-N- ethoxyphthalimido-3-(substituted phenyl)-4-methyl-3a,6-dihydro pyrazolo[3,4-c]pyrazol2(3H)-yl(pyridin-3-yl)methanone (5a-d). All the synthesized compounds have been characterized by elemental analysis and spectral data and were screened for various anti-microbial and antiviral activities.