An increased rate of longitudinal cognitive decline is observed in Parkinson's disease patients with low CSF A beta 42 and an APOE epsilon 4 allele

摘要

Objective: Low concentrations of cerebrospinal fluid (CSF) amyloid-beta (A beta-42) are associated with increased risk of cognitive decline in Parkinson's disease (PD). We sought to determine whether APOE genotype modifies the rate of cognitive decline in PD patients with low CSF A beta-42 compared to patients with normal levels.