The antitumorigenic roles of BRCA1-BARD1 in DNA repair and replication

摘要

BRCA1 and its partner BARD1 support repair of double-strand breaks by homologous recombination and protect replication forks from damage. Recent studies have improved our understanding of the molecular mechanisms of these tumour-suppressive functions of BRCA1-BARD1 and how they are subverted in therapy-resistant cancers.