The Influence of A118G Single Nucleotide Polymorphism of Human Mu Opioid Receptor Gene and the MDR1 Gene in Egyptian Patients With Tramadol-induced Seizure

摘要

Objectives: Although seizures have been reported with tramadol use, the exact mechanism is not yet confirmed. An individual genetic susceptibility may have a role in developing seizures. The purpose of this study was to investigate the frequency of mutant allele of the OPRM A118G and MDR1 C3534T in tramadol users with seizures. Methods: After investigators obtained informed consent and when other causes of seizures were excluded, 74 Egyptian tramadol users, with and without seizures, were assessed clinically, radiologically, and by elec- troencephalogram. Their blood samples were geno- typed for the mu-opioid receptor gene and the multidrug resistant (MDR1) genes. Results: Thirty-seven subjects had seizures. A history of head trauma and more opioid use were reported by the group with seizures. Family history of epilepsy was present in 2 subjects with seizures. There was no significant difference between the 2 groups with regard to the frequency of occurrence of the SNP A118G of the mu opioid receptor gene or the SNP C3435T of the MDR1 gene. Conclusions: This study could not illustrate a potential genetic background in the studied point mutations that could explain the development of tramadol-induced seizures.